A systematic review and participant-level meta-analysis found little association of retinal microvascular caliber with reduced kidney function
| Autor: | Paul Mitchell, Caroline C W Klaver, Ching-Yu Cheng, Annette Kifley, Riswana Banu Binte Mohammed Abdul, Chelsea E. Myers, Alexander P. Maxwell, Tien Yin Wong, Christopher Patterson, Weng Kit Lye, Charumathi Sabanayagam, Kunihiro Matsushita, E. Shyong Tai, Michael G. Shlipak, Euan N Paterson, Unal Mutlu, Takamasa Kayama, Mark J. Sarnak, Hidetoshi Yamashita, Gareth J. McKay, Ronald Klein, Mohammad Arfan Ikram, Barbara E.K. Klein |
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| Přispěvatelé: | Epidemiology, Ophthalmology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Population 030232 urology & nephrology Renal function Kidney Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Ophthalmology medicine Humans education Retina education.field_of_study business.industry Retinal Vessels Retinal medicine.disease Confidence interval Arterioles Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure chemistry Nephrology Meta-analysis Relative risk business Glomerular Filtration Rate Kidney disease |
| Zdroj: | Lye, W K, Paterson, E, Patterson, C C, Maxwell, A P, Binte Mohammed Abdul, R B, Tai, E S, Cheng, C Y, Kayama, T, Yamashita, H, Sarnak, M, Shlipak, M, Matsushita, K, Mutlu, U, Ikram, M A, Klaver, C, Kifley, A, Mitchell, P, Myers, C, Klein, B E, Klein, R, Wong, T Y, Sabanayagam, C & McKay, G J 2020, ' A systematic review and participant-level meta-analysis found little association of retinal microvascular caliber and reduced kidney function ', Kidney International, vol. 2020, pp. 1 . https://doi.org/10.1016/j.kint.2020.06.033 Kidney International, 99(3), 696-706. Elsevier Inc. Kidney Int |
| ISSN: | 1523-1755 0085-2538 |
| DOI: | 10.1016/j.kint.2020.06.033 |
| Popis: | Previously, variation in retinal vascular caliber has been reported in association with chronic kidney disease (CKD) but findings remain inconsistent. To help clarify this we conducted individual participant data meta-analysis and aggregate data meta-analysis on summary estimates to evaluate cross-sectional associations between retinal vascular caliber and CKD. A systematic review was performed using Medline and EMBASE for articles published until October 2018. The aggregate analysis used a two-stage approach combining summary estimates from eleven studies (44,803 patients) while the individual participant analysis used a one-stage approach combining raw data from nine studies (33,222 patients). CKD stages 3-5 was defined as an estimated glomerular filtration rate under 60 mL/min/1.73m2. Retinal arteriolar and venular caliber (central retinal arteriolar and venular equivalent) were assessed from retinal photographs using computer-assisted methods. Logistic regression estimated relative risk of CKD stages 3-5 associated with a 20 μm decrease (approximately one standard deviation) in central retinal arteriolar and venular equivalent. Prevalence of CKD stages 3-5 was 11.2% of 33,222 and 11.3% of 44,803 patients in the individual participant and aggregate data analysis, respectively. No significant associations were detected in adjusted analyses between central retinal arteriolar and venular equivalent and CKD stages 3-5 in the aggregate analysis for central retinal arteriolar relative risk (0.98, 95% confidence interval 0.94-1.03); venular equivalent (0.99, 0.95-1.04) or individual participant central retinal arteriolar (0.99, 0.95-1.04) or venular equivalent (1.01, 0.97-1.05). Thus, meta-analysis provided little evidence to suggest that cross sectional direct measurements of retinal vascular caliber was associated with CKD stages 3-5 in the general population. Hence, meta-analyses of longitudinal studies evaluating the association between retinal parameters and CKD stages 3-5 may be warranted. |
| Databáze: | OpenAIRE |
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