Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
| Autor: | Li-Tzong Chen, Hui Chen Hsu, Ming-Shiang Wu, Chi Long Chen, Shin-Lian Doong, Sung-Hsin Kuo, Ann-Lii Cheng, Tsui Lien Mao, Jaw-Town Lin, Kun-Huei Yeh, Yi Shin Tzeng |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Immunology Active Transport Cell Nucleus Biology Biochemistry Gastroenterology Translocation Genetic Helicobacter Infections Predictive Value of Tests Stomach Neoplasms Internal medicine medicine Gastric mucosa Humans Helicobacter B cell Adaptor Proteins Signal Transducing Aged Cell Nucleus Helicobacter pylori Chromosomes Human Pair 11 Stomach NF-kappa B MALT lymphoma Lymphoma B-Cell Marginal Zone Cell Biology Hematology Middle Aged B-Cell CLL-Lymphoma 10 Protein medicine.disease biology.organism_classification BCL10 Lymphoma Treatment Outcome medicine.anatomical_structure Female Chromosomes Human Pair 18 Biomarkers |
| Zdroj: | Blood. 106:1037-1041 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-kappaB) was recently found to be closely associated with H pylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P < .001). Nuclear expression of NF-kappaB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P < .001). Further, nuclear translocation of BCL10 and NF-kappaB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-kappaB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21). |
| Databáze: | OpenAIRE |
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