Functional genome annotation depicts probiotic properties of Bacillus velezensis FTC01
| Autor: | Ana Carolina Ritter, Samuel Paulo Cibulski, Jamile Queiroz Pereira, Adriano Brandelli |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
DNA Bacterial In silico Bacillus Biology Genome 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bacterial Proteins Gene cluster Genetics Gene Phylogeny Peptidylprolyl isomerase Probiotics General Medicine Genome project Sequence Analysis DNA 030104 developmental biology chemistry 030220 oncology & carcinogenesis GenBank Metabolome Surfactin Genome Bacterial |
| Zdroj: | Gene. 713 |
| ISSN: | 1879-0038 |
| Popis: | An in silico genome analysis of the probiotic Bacillus strain FTC01 was performed. The draft genome comprises 3.9 Mb, with a G + C content of 46.6% and a total of 3941 coding sequences. The species of strain FTC01 was defined as B. velezensis during GenBank genome annotation, following the current nomenclature. Eight gene clusters involved in the synthesis of non-ribosomal lipopeptides, polyketides and bacilysin were found, as well as part of the gene cluster involved in the synthesis of cyclic lipopeptide locillomycin. The production of lipopeptides surfactin and iturin by strain FTC01 was confirmed. In addition, a gene encoding a peptidylprolyl isomerase, involved in bacterial adhesion to the host tissue, beyond twelve genes responsible for acid tolerance and several hydrolase genes were found. These characteristics may help in host colonization and maintenance and may account for the probiotic properties observed for strain FTC01. |
| Databáze: | OpenAIRE |
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