Author Correction: Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
| Autor: | Rahi Patel, Wayne O. Miles, R. Ranjith Kumar, Wilhelm Haas, Brandon Nicolay, Chenyu Lin, Benedikt Obermayer, Robert Morris, Capucine Van Rechem, Myriam Boukhali, Emanuel Wyler, Nicholas J. Dyson, Swetha Rajasekaran, Jessica B. Rakijas, Eshan Khan, Christine Vogel, Markus Landthaler, Jayashree Balasubramanyam, Jalal K. Siddiqui, Sailaja Elchuri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Computer science Retinal Neoplasms Ubiquitin-Protein Ligases Retinoblastoma Medicine (miscellaneous) Data science Cancer metabolism General Biochemistry Genetics and Molecular Biology Mice Retinoblastoma Binding Proteins Cell Line Tumor Multi omics Animals Humans Biology (General) Cellular programming General Agricultural and Biological Sciences Author Correction Tumour-suppressor proteins Transcriptomics |
| Zdroj: | Communications Biology Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021) |
| ISSN: | 2399-3642 |
| Popis: | Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of how RB-loss changes human cells. Here we show that pRB-depletion results in cellular reprogramming, we quantitatively measured how RB-depletion altered the transcriptional, proteomic and metabolic output of non-tumorigenic RPE1 human cells. These profiles identified widespread changes in metabolic and cell stress response factors previously linked to E2F function. In addition, we find a number of additional pathways that are sensitive to RB-depletion that are not E2F-regulated that may represent compensatory mechanisms to support the growth of RB-depleted cells. To determine whether these molecular changes are also present in RB1 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink