Possible evaluation of hemodynamic effects of the potassium channel opener KRN2391 on induced hypotension in dogs
| Autor: | Noriko Tashiro, Takeda S |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure business.industry Cardiac index Hemodynamics Stroke volume medicine.anatomical_structure Anesthesiology and Pain Medicine Afterload Anesthesia Internal medicine Cardiology medicine Vascular resistance Potassium channel opener Pulmonary wedge pressure business |
| Zdroj: | Journal of Anesthesia. 11 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s0054070110136 |
| Popis: | KRN2391 is potassium channel opener with a nitrate moiety which possesses potent vasodilatory action. The hemodynamic profiles of KRN2391-induced hypotension are still not well understood. The aim of this study was to investigate the potential use of KRN2391 for induced hypotension. Eight dogs were anesthetized with 0.87% halothane in oxygen (1 MAC). After the baseline period, mean arterial pressure (MAP) was reduced to 60 mmHg for 60 min by the infusion of KRN2391. MAP was reduced approximately 50% and was associated with a 80% maximum reduction (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink