Presence of HIV drug resistance in antiretroviral therapy-naive and -experienced patients from Papua New Guinea
| Autor: | Matthew David, Peter Siba, Petronia Kaima, Anna C. Hearps, Angela Kelly-Hanku, Ulato Imara, Janet Gare, Zure Kombati, Claire Ryan, Suzanne M. Crowe, Diana Timbi |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Cyclopropanes Male Microbiology (medical) medicine.medical_specialty Nevirapine Adolescent Anti-HIV Agents HIV Infections Drug resistance Papua New Guinea Young Adult Zidovudine Antiretroviral Therapy Highly Active Internal medicine Drug Resistance Viral HIV Seropositivity parasitic diseases medicine Humans Pharmacology (medical) Treatment Failure Young adult Pharmacology business.industry Stavudine Lamivudine Middle Aged Viral Load Virology Benzoxazines Infectious Diseases Alkynes HIV-1 Reverse Transcriptase Inhibitors Female Dried Blood Spot Testing business Viral load HIV drug resistance medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 69:2183-2186 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dku089 |
| Popis: | OBJECTIVES: The optimal benefits of antiretroviral therapy (ART) can be compromised by the emergence of HIV drug resistance (HIVDR) resulting in treatment failure. ART was introduced in Papua New Guinea (PNG) in 2004, yet biological data on HIVDR are lacking. The aim of the study was to investigate levels of HIVDR in ART-naive and -experienced patients in PNG. METHODS: We recruited, interviewed and collected blood from 108 ART-naive and 102 ART-experienced patients from two Highlands provinces of PNG. Dried blood spots were tested for HIVDR from all patients with detectable plasma viral load of ≥200 copies/mL using established in-house assays. RESULTS: The PCR amplification success was 90.6% (n = 96) and 66.7% (n = 12) using dried blood spots from ART-naive and -experienced patients, respectively. Transmitted drug resistance was detected in 2.1% (n = 2) of samples from ART-naive patients; acquired drug resistance was detected in 50% (n = 6) of samples from ART-experienced individuals. CONCLUSIONS: Our data showed that transmitted drug resistance in PNG is low and acquired drug resistance is higher with 12.7% of the ART-experienced patients failing treatment. As ART access is rapidly expanding in PNG, monitoring of drug resistance is paramount for early detection of treatment failure. |
| Databáze: | OpenAIRE |
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