Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats
| Autor: | Sandra Maesta-Pereira, Mimi Q La-Vu, Shiyu Ji, Brooke C Tobias, Alcino J. Silva, Anita Torossian, Newton S. Canteras, Peter J Schuette, Avishek Adhikari, Fernando M. C. V. Reis, Megha Sehgal, Weisheng Wang, Tor D. Wager, Philip A. Kragel, Jonathan C. Kao, Marta Ceko, Meghmik Chakerian |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Time Factors predator Hypothalamus Posterior Video Recording panic Central node Escape Reaction Conditioning Psychological Neural Pathways Periaqueductal Gray Biology (General) Cholecystokinin Brain Mapping medicine.diagnostic_test Behavior Animal dorsal premammillary nucleus General Neuroscience General Medicine Fear Magnetic Resonance Imaging Visual Perception Medicine Female Dorsum Adult QH301-705.5 Science Mice Transgenic Biology Periaqueductal gray General Biochemistry Genetics and Molecular Biology Young Adult medicine Animals Humans Rats Long-Evans General Immunology and Microbiology HIPOTÁLAMO Escape velocity Mice Inbred C57BL Optogenetics Dorsal premammillary nucleus escape Functional magnetic resonance imaging Neuroscience Photic Stimulation |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP eLife, Vol 10 (2021) |
| Popis: | Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (PMd) are necessary for initiating escape from innate threats via a projection to the dorsolateral periaqueductal gray (dlPAG). We now show that in mice PMd-cck cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity can also predict future escape. Furthermore, PMd inhibition decreases escape speed from both innate and conditioned threats. Inhibition of the PMd-cck projection to the dlPAG also decreased escape speed. Intriguingly, PMd-cck and dlPAG activity in mice showed higher mutual information during exposure to innate and conditioned threats. In parallel, human functional magnetic resonance imaging data show that a posterior hypothalamic-to-dlPAG pathway increased activity during exposure to aversive images, indicating that a similar pathway may possibly have a related role in humans. Our data identify the PMd-dlPAG circuit as a central node, controlling escape vigor elicited by both innate and conditioned threats. |
| Databáze: | OpenAIRE |
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