MRI characterization of diffusion coefficients in a rat spinal cord injury model
| Autor: | David B. Hackney, John C. Ford, Peter M. Joseph, Hernan Jara, Perry Black, Christopher M. Hand, David C. Alsop |
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| Rok vydání: | 1994 |
| Předmět: |
Copper Sulfate
Hot Temperature Materials science Cord Diffusion Anisotropy Diffusion White matter Nuclear magnetic resonance medicine Animals Radiology Nuclear Medicine and imaging Longitudinal axis Spinal cord injury Spinal Cord Injuries medicine.diagnostic_test Reproducibility of Results Water Magnetic resonance imaging Anatomy Image Enhancement medicine.disease Spinal cord Magnetic Resonance Imaging Mr imaging Rats Models Structural body regions medicine.anatomical_structure Spinal Cord Copper |
| Zdroj: | Magnetic Resonance in Medicine. 31:488-494 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1910310504 |
| Popis: | Apparent diffusion coefficients (ADC) were measured in a rat spinal cord weight-drop injury model. After sacrifice, the spinal cords were fixed in situ and excised for MR imaging and ADC measurement. Diffusion is anisotropic in normal gray and white matter. There were significant decreases in ADCs measured along the longitudinal axis of the injured cord and increases in ADCs measured transverse to the cord. Injured segments demonstrated reductions in diffusion anisotropy in the white matter. Diffusion was completely isotropic at the epicenter of the weight-drop injury. Significant decreases in longitudinal ADC and increases in transverse ADC were observed in portions of the cord which appeared normal on conventional spin-echo and calculated T2 images. Thus ADC measurement may complement routine imaging for evaluation of spinal cord injury. |
| Databáze: | OpenAIRE |
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