Assessment of bisphenol A exposure in Korean pregnant women by physiologically based pharmacokinetic modeling
| Autor: | Jong Bong Lee, Joong San Park, Beom Soo Shin, Sun Dong Yoo, Sang Wook Hwang, Do Jung Kim, Min Chang Kwon, Jürgen B. Bulitta, Hae-Seong Yoon, Seung Du Yang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Tolerable daily intake
Adult Male endocrine system Physiologically based pharmacokinetic modelling Health Toxicology and Mutagenesis Glucuronidation Physiology Administration Oral Absorption (skin) Pharmacology Toxicology Models Biological Rats Sprague-Dawley Pharmacokinetics Phenols Oral administration Pregnancy Republic of Korea Medicine Animals Humans Estrogens Non-Steroidal Benzhydryl Compounds Reference dose urogenital system business.industry Environmental exposure Environmental Exposure Rats Maternal Exposure Environmental Pollutants Female business hormones hormone substitutes and hormone antagonists Environmental Monitoring |
| Zdroj: | Journal of toxicology and environmental health. Part A. 73(21-22) |
| ISSN: | 1528-7394 |
| Popis: | The objective of this study was to predict the exposure to bisphenol A (BPA) after oral intake in human blood and tissues using physiologically based pharmacokinetic (PBPK) modeling. A refined PBPK model was developed taking into account of glucuronidation, biliary excretion, and slow absorption of BPA in order to describe the second peak of BPA observed following oral intake. This developed model adequately described the second peak and BPA concentrations in blood and various tissues in rats after oral administration. A prospective validation study in rats additionally supported the proposed model. For extrapolation to humans, a daily oral BPA dose of 0.237 mg/70 kg/d or 0.0034 mg/kg/d was predicted to achieve an average steady-state blood concentration of 0.0055 ng/ml (median blood BPA concentration in Korean pregnant women). This dose was lower than the reference dose (RfD, 0.016 mg/kg/d) and the tolerable daily intake established by the European Commission (10 μg/kg/d). Data indicate that enterohepatic recirculation may be toxicologically important as this pathway may increase exposure and terminal half-life of BPA in humans. |
| Databáze: | OpenAIRE |
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