Biochemical Diagnosis of Alzheimer Disease by Measuring the Cerebrospinal Fluid Ratio of Phosphorylated tau Protein to β-Amyloid Peptide42
| Autor: | Britta Müller-Tillmanns, Thomas Hegi, Alessia Maddalena, Christoph Hock, Roger M. Nitsch, Hans H. Jung, Andreas Papassotiropoulos |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Genotype Amyloid Tau protein Enzyme-Linked Immunosorbent Assay Neuropsychological Tests Protein Serine-Threonine Kinases Sensitivity and Specificity Central nervous system disease Glycogen Synthase Kinase 3 Apolipoproteins E Degenerative disease Cerebrospinal fluid Arts and Humanities (miscellaneous) Alzheimer Disease mental disorders medicine Humans Dementia Aged Aged 80 and over Amyloid beta-Peptides biology business.industry Antemortem Diagnosis Antibodies Monoclonal Middle Aged medicine.disease Peptide Fragments ROC Curve biology.protein Female Neurology (clinical) Alzheimer's disease business |
| Zdroj: | Archives of Neurology. 60 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.60.9.1202 |
| Popis: | BACKGROUND: The antemortem diagnosis of Alzheimer disease (AD) requires time-consuming and costly procedures. Therefore, biochemical tests that can direct the physician rapidly to the correct diagnosis are highly desirable. Measurement of single biochemical markers in cerebrospinal fluid (CSF), such as total tau protein and beta-amyloid peptide42 (Abeta42), shows robust alterations that highly correlate with the clinical diagnosis of AD but generally lack sufficient diagnostic accuracy. OBJECTIVE: To study the combination of CSF phosphorylated tau protein (phospho-tau) and Abeta42 as biochemical markers for AD. METHODS: We combined CSF measurements of phospho-tau and Abeta42 in 100 consecutive patients who under-went diagnostic workup for dementia and in 31 healthy control subjects. RESULTS: We found that the calculated ratio of phospho-tau to Abeta42 was significantly increased in patients with AD and provided high diagnostic accuracy in distinguishing patients with AD from healthy control subjects (sensitivity, 86%; specificity, 97%), subjects with non-AD dementias (sensitivity, 80%; specificity, 73%), and subjects with other neurological disorders (sensitivity, 80%; specificity, 89%). CONCLUSION: The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia. |
| Databáze: | OpenAIRE |
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