Primary intestinal T cell lymphomas in Indian patients--in search of enteropathic T cell lymphoma
| Autor: | Sumeet Gujral, Reena Nair, Munita Bal, Arti Karpate, Tanuja Shet, Sudeep Gupta |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Adult Male Pathology medicine.medical_specialty Epstein-Barr Virus Infections Herpesvirus 4 Human Adolescent T cell CD3 lcsh:QR1-502 India Biology medicine.disease_cause Lymphoma T-Cell lcsh:Microbiology Pathology and Forensic Medicine T cell lymphoma Immunophenotyping Intestinal Neoplasms medicine lcsh:Pathology T-cell lymphoma Celiac disease Humans General Medicine Middle Aged medicine.disease Epstein–Barr virus intestinal lymphoma Lymphoma Granzyme B Gastrointestinal Tract medicine.anatomical_structure enteropathy biology.protein Female CD8 lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 53, Iss 3, Pp 455-459 (2010) Scopus-Elsevier |
| ISSN: | 0974-5130 |
| Popis: | Objective: This series of six intestinal T cell lymphomas (ITCL) attempts to document enteropathy-associated T cell lymphoma (EATCL) in India. Materials and Methods: A total of six ITCL were selected from 170 gastrointestinal lymphomas in last 10 years. Results: The cases studied included EATCL (4), ITCL with a CD4 positive phenotype (1) and ITCL NK/T cell type (1). Of the four EATCL, two occurred in the ileum, one in right colon and one in duodenum. In three EATCL cases, there was history of celiac disease or lactose intolerance and enteropathic changes were noted in the adjacent mucosa. These tumors had CD3+/CD8+/CD56 (+/-)/CD4-/ Granzyme B+ immunophenotype. One EATCL was monomorphic small cell type (type II EATCL) with a CD3+/CD8-CD56+/CD4-/ Granzyme B+ phenotype. EBER- ISH (Epstein Barr virus coded RNA′s- in situ hybridization) revealed positive tumor cells in ITCL NK/T cell type and in bystander cells in three EATCL. Conclusion: ITCL are rare in Indian patients but do occur and comprise a mixture of the enteropathic and non-enteropathic subtypes. |
| Databáze: | OpenAIRE |
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