Immunogenicity of High Dose Influenza Vaccine for Patients with Inflammatory Bowel Disease on Anti-TNF Monotherapy: A Randomized Clinical Trial
Autor: | Abigail R. Sharpe, Sumona Saha, Freddy Caldera, Arnold Wald, Mary S. Hayney, Ian Grimes, Youqi Zhang, Luke Hillman, Mark Reichelderfer |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Influenza vaccine Antibodies Monoclonal Humanized Antibodies Viral Gastroenterology Inflammatory bowel disease law.invention Vedolizumab Immunogenicity Vaccine Influenza A Virus H1N1 Subtype Randomized controlled trial Interquartile range law Internal medicine Influenza Human medicine Immunology and Allergy Humans Crohn's disease business.industry Immunogenicity Influenza A Virus H3N2 Subtype Vaccination Hemagglutination Inhibition Tests Middle Aged medicine.disease Inflammatory Bowel Diseases Ulcerative colitis Influenza B virus Influenza Vaccines Female Tumor Necrosis Factor Inhibitors business medicine.drug |
Zdroj: | Inflammatory bowel diseases. 26(4) |
ISSN: | 1536-4844 |
Popis: | BackgroundPatients with inflammatory bowel disease (IBD) on anti-tumor necrosis factor alpha (TNF) agents may have lower immune response to the influenza vaccine. We aimed to evaluate the immunogenicity of the high dose (HD) vs standard dose (SD) influenza vaccine in patients with IBD on anti-TNF monotherapy.MethodsWe performed a randomized clinical trial at a single academic center evaluating the immunogenicity of the HD vs SD influenza vaccine in patients with IBD on anti-TNF monotherapy. Influenza antibody concentration was measured at immunization, at 2 to 4 weeks postimmunization, and at 6 months.ResultsSixty-nine patients with IBD were recruited into the study, 40 on anti-TNF monotherapy, and 19 on vedolizumab, along with 20 healthy controls (HC). Patients with IBD receiving the HD influenza vaccine had significantly higher H3N2 postimmunization antibodies compared with those who received the SD influenza vaccine (160 [interquartile range 80 to 320] vs 80 [interquartile range 40 to 160]; P = 0.003). The H1N1 postimmunization levels were not significantly higher in the HD influenza vaccine (320 [interquartile range 150 to 320] vs 160 [interquartile range 80 to 320]; P = 0.18). Patients with IBD receiving the HD influenza vaccine and those on vedolizumab who received SD had equivalent antibody concentrations to HC (H1N1 P = 0.85; H3N2 P = 0.23; B/Victoria P = 0.20 and H1N1 P = 0.46; H3N2 P = 0.21; B/Victoria P = 1.00, respectively).ConclusionsPatients with IBD on anti-TNF monotherapy receiving the HD influenza vaccine had significantly higher postimmunization antibody levels compared with SD vaccine. Clinicaltrials.gov (#NCT02461758). |
Databáze: | OpenAIRE |
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