Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
| Autor: | Vivian Garzón, Rosa-Helena Bustos, Daniel G Pinacho |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty medicine.drug_class media_common.quotation_subject Antibiotics lcsh:Medicine Medicine (miscellaneous) Review 01 natural sciences therapeutic drug monitoring (TDM) antibiotic 03 medical and health sciences Pharmacokinetics medicine Intensive care medicine media_common 0303 health sciences medicine.diagnostic_test 030306 microbiology business.industry lcsh:R 010401 analytical chemistry personalized medicine Toxic dose biosensors 0104 chemical sciences Therapeutic drug monitoring Pharmacodynamics Personalized medicine business |
| Zdroj: | Journal of Personalized Medicine, Vol 10, Iss 147, p 147 (2020) Journal of Personalized Medicine |
| ISSN: | 2075-4426 |
| DOI: | 10.3390/jpm10040147 |
| Popis: | Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer. This review describes recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental aspect of personalized medicine. |
| Databáze: | OpenAIRE |
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