PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors
| Autor: | Duygu Uckan, Ozlen Konu, Erdal Cosgun, Ilgin Cagnan, Aysen Gunel-Ozcan |
|---|---|
| Přispěvatelé: | Konu, Özlen |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Diepoxybutane Biology 03 medical and health sciences chemistry.chemical_compound Bone marrow mesenchymal stem cells 0302 clinical medicine Downregulation and upregulation Fanconi anemia TGF-β1 Gene expression Genetics medicine TALE class Molecular Biology Transcription factor Mesenchymal stem cell General Medicine medicine.disease HOX genes FANCA 3. Good health 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Cancer research Bone marrow PKNOX2 |
| Zdroj: | Molecular Biology Reports |
| Popis: | HOX and TALE transcription factors are important regulators of development and homeostasis in determining cellular identity. Deregulation of this process may drive cancer progression. The aim of this study was to investigate the expression of these transcription factors in the bone marrow derived mesenchymal stem cells (BM-MSCs) of Fanconi anemia (FA) patients, which is a cancer-predisposing disease. Expression levels of HOX and TALE genes in BM-MSCs were obtained from FA patients and healthy donors by RT-qPCR and highly conserved expression levels were observed between patient and donor cells, except PKNOX2, which is a member of TALE class. PKNOX2 was significantly downregulated in FA cells compared to donors (P |
| Databáze: | OpenAIRE |
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