Ral signaling pathway in health and cancer
| Autor: | Elham Patrad, Warner Peng, Naeimeh Tavakolinia, Timothy J. Pluard, Brandon Ricke, Elham Tafsiri, Anthony Accurso, Benjamin Fangman, Roya Dolatkhah, Faris Farassati, Robyn Gartell, Michael Salacz, Mina Yazdi, Saeid Ghavami, Zohreh Sanaat, Mohammad Mazani, Kushal J. Shah, Leland Graves, Danse Bi, Kyle Kimura, Adel Rezaei Moghadam, Marzieh Khajoie Najad, Tuba Esfandyari, Zaid Naima, Mojtaba Amani, Colleen Reilly |
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| Rok vydání: | 2017 |
| Předmět: |
cancer stem cells
0301 basic medicine Cancer Research Protein Conformation Review Disease Biology Structure-Activity Relationship 03 medical and health sciences Aurora kinase Cancer stem cell Neoplasms Aurora Kinase medicine cancer Animals Humans Radiology Nuclear Medicine and imaging Cancer Biology Oncolytic Virotherapy therapy biology Effector Cancer medicine.disease RALA Cell biology Ral Oncolytic Viruses 030104 developmental biology Oncology Mutation Cancer cell Neoplastic Stem Cells ral GTP-Binding Proteins Signal transduction Signal Transduction |
| Zdroj: | Cancer Medicine |
| ISSN: | 2045-7634 |
| Popis: | The Ral (Ras‐Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and malignant peripheral nerve sheath tumors. Additionally, we have shown that the activation of RalA in cancer stem cells is higher in comparison with differentiated cancer cells. In this article, we review the role of Ral signaling in health and disease with a focus on the role of this multifunctional protein in the generation of therapies for cancer. An improved understanding of this pathway can lead to development of a novel class of anticancer therapies that functions on the basis of intervention with RalA or its downstream effectors. |
| Databáze: | OpenAIRE |
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