Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders

Autor: Ming Wang, Kwok-Hung Chan, Kenneth S. M. Li, Chung-Tong Shek, Garnet K. Y. Choi, Bo-Jian Zheng, Patrick C. Y. Woo, Carol S. F. Lam, Rachel Y.Y. Fan, Rongtong Guo, Beatrice H.L. Wong, Rosana W.S. Poon, Sylvia Y. H. Wang, Kwok-Yung Yuen, Alan K.L. Tsang, Susanna K. P. Lau
Přispěvatelé: Plazi
Rok vydání: 2012
Předmět:
Most recent common ancestor
Adaptation
Biological
medicine.disease_cause
Alphacoronavirus
Chiroptera
Cluster Analysis
Viral
Viridae
Phylogeny
Coronavirus
Genome
Phylogenetic tree
biology
Hipposideros pomona
biotic associations
corona viruses
Infectious
covid
covid-19
Hong Kong
RNA
Viral
Coronavirus Infections
Sequence Analysis
CETAF-taskforce
Rhinolophus
Coronaviridae
Evolution
Immunology
Molecular Sequence Data
Zoology
Genome
Viral
Microbiology
virus-host
Evolution
Molecular
Disease Transmission
Phylogenetics
pathogen-host
Virology
medicine
Disease Transmission
Infectious
Animals
biotic relations
Adaptation
Body Weight
Molecular
Insectivore
pathogens
DNA
Sequence Analysis
DNA
biology.organism_classification
Biological
biotic interaction
Genetic Diversity and Evolution
Insect Science
Asymptomatic Diseases
RNA
Zdroj: Journal of Virology
ISSN: 1098-5514
Popis: Although coronaviruses are known to infect various animals by adapting to new hosts, interspecies transmission events are still poorly understood. During a surveillance study from 2005 to 2010, a novel alphacoronavirus, BatCoV HKU10, was detected in two very different bat species, Ro-BatCoV HKU10 in Leschenault's rousettes ( Rousettus leschenaulti ) (fruit bats in the suborder Megachiroptera) in Guangdong and Hi-BatCoV HKU10 in Pomona leaf-nosed bats ( Hipposideros pomona ) (insectivorous bats in the suborder Microchiroptera) in Hong Kong. Although infected bats appeared to be healthy, Pomona leaf-nosed bats carrying Hi-BatCoV HKU10 had lower body weights than uninfected bats. To investigate possible interspecies transmission between the two bat species, the complete genomes of two Ro-BatCoV HKU10 and six Hi-BatCoV HKU10 strains were sequenced. Genome and phylogenetic analyses showed that Ro-BatCoV HKU10 and Hi-BatCoV HKU10 represented a novel alphacoronavirus species, sharing highly similar genomes except in the genes encoding spike proteins, which had only 60.5% amino acid identities. Evolution of the spike protein was also rapid in Hi-BatCoV HKU10 strains from 2005 to 2006 but stabilized thereafter. Molecular-clock analysis dated the most recent common ancestor of all BatCoV HKU10 strains to 1959 (highest posterior density regions at 95% [HPDs], 1886 to 2002) and that of Hi-BatCoV HKU10 to 1986 (HPDs, 1956 to 2004). The data suggested recent interspecies transmission from Leschenault's rousettes to Pomona leaf-nosed bats in southern China. Notably, the rapid adaptive genetic change in BatCoV HKU10 spike protein by ∼40% amino acid divergence after recent interspecies transmission was even greater than the ∼20% amino acid divergence between spike proteins of severe acute respiratory syndrome-related Rhinolophus bat coronavirus (SARSr-CoV) in bats and civets. This study provided the first evidence for interspecies transmission of coronavirus between bats of different suborders.
Databáze: OpenAIRE
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