The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States
| Autor: | Richard D. Lozano, Manal M. Hassan, Adel S. El-Deeb, Katrina Y. Glover, Nga Nguyen, Wenyaw Chan, Yehuda Z. Patt, Ahmed Kaseb, Melanie B. Thomas, James L. Abbruzzese, Steven A. Curley, Margret R. Spitz, Steven H. Wei, Donghui Li, Jean Nicolas Vauthey |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Pathology Carcinoma Hepatocellular medicine.disease_cause Article Risk Factors Internal medicine medicine Humans Prospective Studies First-degree relatives Family history Aged Hepatitis B virus Hepatology business.industry Liver Neoplasms Cancer Hepatitis C Hepatitis B Middle Aged medicine.disease digestive system diseases United States Hepatocellular carcinoma Case-Control Studies Female Liver cancer business |
| Zdroj: | Journal of hepatology. 50(2) |
| ISSN: | 0168-8278 |
| Popis: | Background/Aims The study aimed at addressing the connection between positive family history of liver cancer and hepatocellular carcinoma (HCC) development in the USA. Methods At The University of Texas M.D. Anderson Cancer Center, 347 patients with pathologically confirmed HCC and 1075 healthy controls were studied. All subjects were interviewed for their family history of cancer, including the number of relatives with cancer, the type of cancer, the individual's relationship with the relative, and the age at which the relative was diagnosed. Results Independently of hepatitis B virus (HBV) and hepatitis C virus (HCV), a history of liver cancer in first degree relatives was significantly associated with HCC development (AOR=4.1 [95% CI, 1.3–12.9]). Multiple relatives with liver cancer were only observed among HCC patients with chronic HBV/HCV infection. Affected siblings with liver cancer is significantly associated with HCC development with and without HBV/HCV infection; (AOR=5.7 [95% CI, 1.2–27.3]) and (AOR=4.3 [95% CI, 1.01–20.9]), respectively. Individuals with HBV/HCV and a family history of liver cancer were at higher risk for HCC (AOR=61.9 [95% CI, 6.6–579.7]). Conclusions First degree family history of liver cancer is associated with HCC development in the USA. Further research exploring the genetic-environment interactions associated with risk of HCC is warranted. |
| Databáze: | OpenAIRE |
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