Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term
| Autor: | Rodrigo Pauperio Soares de Camargo, Laura Fernandes Martin, Hélio Amante Miot, Karayna Gil Fernandes, Márcia Guimarães da Silva, Stephanno Gomes Pereira Sarmento, Natália Prearo Moço, Bruna Ribeiro de Andrade Ramos, Dionísio Chiaratto Filho |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Jundiaí Medical School, Universidade Estadual de Maringá (UEM) |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Myeloid Amniotic fluid Inflammatory response Pregnancy Trimester Third Immune receptor Biology 03 medical and health sciences Young Adult Pregnancy medicine Humans Receptors Immunologic Receptor Innate immunity Soluble receptors Innate immune system Membrane Glycoproteins Obstetrics and Gynecology Amniotic Fluid Immunity Innate Triggering Receptor Expressed on Myeloid Cells-1 Cell biology Membrane glycoproteins 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Immunology Myeloid cells biology.protein Female |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1423-002X |
| Popis: | Made available in DSpace on 2018-12-11T17:03:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01 Background: Triggering receptors expressed on myeloid cells-1 (TREM-1) are innate immune receptors that mediate inflammatory response. In recent times, the role of these receptors has become the focus of several studies in the gestational context. Evaluation of soluble TREM-1 concentration in normal pregnancy is scarce, and no data are available on the levels of this receptor in the last weeks of normal pregnancy. Method: Amniotic fluid (AF) samples were obtained from 77 patients in the last weeks of normal pregnancy during cesarean section, and the soluble form of TREM-1 (sTREM-1) levels determined using specific sandwich enzyme-linked immunosorbent assay kit. Results: sTREM-1 was detectable in all AF samples, and its levels did not vary in the last weeks of third trimester pregnancy. There was no correlation between sTREM-1 levels in AF and advancing gestational age. Conclusion: sTREM-1 is a physiologic constituent of AF and its levels are not temporally regulated in pregnancies at term. Department of Pathology Botucatu Medical School São Paulo State University UNESP Department of Dermatology Botucatu Medical School São Paulo State University UNESP Department of Obstetrics and Gynecology Jundiaí Medical School Bom Jesus Hospital Department of Pathology Botucatu Medical School São Paulo State University UNESP Department of Dermatology Botucatu Medical School São Paulo State University UNESP |
| Databáze: | OpenAIRE |
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