Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer

Autor: Nurhan Şahin, Rauf Melekoglu, Ayse Gulcin Bastemur, Mehmet Gul, Ebru Inci Coskun, Semir Gul, Ercan Yilmaz, Barış Çıplak
Přispěvatelé: ŞAHİN, NURHAN
Rok vydání: 2018
Předmět:
Adult
0301 basic medicine
Medicine (General)
Nedd4 Ubiquitin Protein Ligases
Gene Expression
a new biomarker in the pathophysiology of endometrial cancer-
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
cilt.46
ss.3709-3716
2018 [YILMAZ E.
GÜL M.
MELEKOĞLU R.
Coskun E. I.
Sahin N.
GÜL S.
BAŞTEMUR A. G.
Ciplak B.
-Neural precursor cell-expressed developmentally down-regulated 4-like]
Adenocarcinoma
medicine.disease_cause
Biochemistry
03 medical and health sciences
R5-920
Polyps
0302 clinical medicine
Ubiquitin
Precursor cell
medicine
Humans
Aged
Retrospective Studies
Uterine Diseases
NEDD4L
biology
business.industry
Endometrial cancer
Biochemistry (medical)
Cancer
Cell Biology
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Endometrial Neoplasms
Cell biology
Endometrial hyperplasia
030104 developmental biology
030220 oncology & carcinogenesis
Endometrial Hyperplasia
biology.protein
Biomarker (medicine)
Female
Carcinogenesis
business
Zdroj: Journal of International Medical Research, Vol 46 (2018)
Popis: Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n = 23), patients with endometrial hyperplasia (Group 2, n = 21) and patients with endometrial cancer (Group 3, n = 20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis.
Databáze: OpenAIRE
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