Cerebral μ-opioid and CB1 receptor systems have distinct roles in human feeding behavior
| Autor: | Laura Pekkarinen, Kari K. Kalliokoski, Tatu Kantonen, Valtteri Kaasinen, Tomi Karjalainen, Jussi Hirvonen, Lauri Nummenmaa, Janne Isojärvi, Pirjo Nuutila |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Cannabinoid receptor Physiology medicine.medical_treatment Receptors Opioid mu Neurosciences. Biological psychiatry. Neuropsychiatry Biology Molecular neuroscience Article Carfentanil 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Receptor Cannabinoid CB1 medicine Humans Receptor Biological Psychiatry Retrospective Studies 030304 developmental biology 2. Zero hunger 0303 health sciences digestive oral and skin physiology Feeding Behavior medicine.disease Obesity Endocannabinoid system Analgesics Opioid Psychiatry and Mental health Eating disorders nervous system Opioid Positron-Emission Tomography Female Cannabinoid Neuroscience 030217 neurology & neurosurgery RC321-571 medicine.drug |
| Zdroj: | Translational Psychiatry Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2158-3188 |
| Popis: | Eating behavior varies greatly between individuals, but the neurobiological basis of these trait-like differences in feeding remains poorly understood. Central μ-opioid receptors (MOR) and cannabinoid CB1 receptors (CB1R) regulate energy balance via multiple neural pathways, promoting food intake and reward. Because obesity and eating disorders have been associated with alterations in the brain’s opioid and endocannabinoid signaling, the variation in MOR and CB1R system function could potentially underlie distinct eating behavior phenotypes. In this retrospective positron emission tomography (PET) study, we analyzed [11C]carfentanil PET scans of MORs from 92 healthy subjects (70 males and 22 females), and [18F]FMPEP-d2 scans of CB1Rs from 35 subjects (all males, all also included in the [11C]carfentanil sample). Eating styles were measured with the Dutch Eating Behavior Questionnaire (DEBQ). We found that lower cerebral MOR availability was associated with increased external eating—individuals with low MORs reported being more likely to eat in response to environment’s palatable food cues. CB1R availability was associated with multiple eating behavior traits. We conclude that although MORs and CB1Rs overlap anatomically in brain regions regulating food reward, they have distinct roles in mediating individual feeding patterns. Central MOR system might provide a pharmacological target for reducing individual’s excessive cue-reactive eating behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|