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Indications in original studies for differential abundance of the three pathofunctions, namely, the formation of trimethylamine (TMA), secondary bile acids lithocholic/deoxycholic acid (LCA/DCA) and hydrogen sulfide (H2S) between patients and respective controls based on functional and taxonomy-based analyses. Data was queried for functions based on function names and KEGG Orthologies (provided for most studies. CutC/D: K20038/K20038, cntA/B: K22443/ K22444, grdH: K21579, baiCD/E: K15870/K15872, dsrA/B: K11180/ K11180). Taxonomic data was screened for key taxa that correlated with function based on information given in Additional file 4 (TMA (cntAB): Escherichia/Klebsiella, TMA (grdH): Dorea, H2S: Bilophila/Desulfovibrio). Clostridium scindens (DCA/LCA) was included as well. Jie et al. [21] (dataset I) additionally analyzed datasets III, VI and X for TMA associated genes based on selected reference sequences and results are also displayed. Forslund et al. [24] included studies III-V into their analysis and reported a trended increase (p = 0.07) for MF0100 (dissimilatory sulfate reduction) in T2D patients across studies. ?: no information on that function/taxa was retrieved, =: no difference between patients and control group, CD: Crohn’s disease, CRC: colorectal cancer, CVD: cardiovascular disease, HGC: high gene count group, MLG: metagenomic linkage group, T2D: type 2 diabetes, UC: ulcerative colitis. (PDF 56 kb) |
