A new flavonoid from the leaves of Garcinia mckeaniana Craib and α-glucosidase and acetylcholinesterase inhibitory activities
| Autor: | Thi Thu Ha Nguyen, Van Tuyen Nguyen, Pham Van Cuong, Tra Nguyen Thanh, Tu Anh Le Thi, Doan Thi Mai Huong, Bich Ngan Truong, Marc Litaudon, Son Ninh The |
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| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2022 |
| Předmět: |
chemistry.chemical_classification
biology Traditional medicine 010405 organic chemistry α glucosidase Organic Chemistry Flavonoid Ethyl acetate Plant Science Inhibitory postsynaptic potential biology.organism_classification 01 natural sciences Biochemistry Acetylcholinesterase 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry [CHIM]Chemical Sciences Garcinia ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Natural Product Research Natural Product Research, Taylor & Francis, 2021, pp.1-11. ⟨10.1080/14786419.2021.1916019⟩ |
| ISSN: | 1478-6419 1029-2349 |
| DOI: | 10.6084/m9.figshare.14531640 |
| Popis: | From the ethyl acetate extract (EtOAc) of the Vietnamese Garcinia mckeaniana leaves, a new flavone 8-C-glycoside 2'',6''-di-O-acetylvitexin (1), together with six known analogs 2-7 were isolated. Their structures were determined by spectral methods and compared with literature data. In α-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 µM, as compared with that of the positive control acarbose (249 µM). Flavones and biflavones showed are better than flavone glycosides in both α-glucosidase and acetylcholinesterase inhibitory activities |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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