Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia

Autor: Simon N. Stacey, Marij J. Stukart, Hetty J. Bontkes, Peter L. Stern, Margaret F. Duggan-Keen, Leszek K. Borysiewicz, René H.M. Verheijen, Jan M. M. Walboomers, Chris J.L.M. Meijer, Rik J. Scheper, Tanja D. de Gruijl, Stephen Man, Adrie J.C. van den Muysenberg
Přispěvatelé: Laboratory Medicine, AGEM - Endocrinology, metabolism and nutrition, Medical oncology laboratory, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Obstetrics and gynaecology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, AII - Cancer immunology, Pathology
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Zdroj: Bontkes, H J, de Gruijl, T D, van den Muysenberg, A J C, Verheijen, R H M, Stukart, M J, Meijer, C J L M, Scheper, R J, Stacey, S N, Duggan-Keen, M F, Stern, P L, Man, S, Borysiewicz, L K & Walboomers, J M M 2000, ' Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia ', International Journal of Cancer, vol. 88, no. 1, pp. 92-98 . https://doi.org/10.1002/1097-0215(20001001)88:1<92::AID-IJC15>3.0.CO;2-E
International Journal of Cancer, 88(1), 92-98. Wiley-Liss Inc.
ISSN: 0020-7136
DOI: 10.1002/1097-0215(20001001)88:1<92::AID-IJC15>3.0.CO;2-E
Popis: Infection with oncogenic human papillomavirus (HPV) types is associated with the development of cervical neoplasia (CIN). The E6 and E7 oncoproteins are constitutively expressed in these lesions and are therefore putative targets for the immune response against HPV. The relation between HPV 16-specific memory cytotoxic T-cell precursor (mCTLp) activity to both oncoproteins and the natural course of cervical dysplasia was analyzed in 38 patients participating in a nonintervention cohort study of women with CIN and II HPV 16-positive cervical carcinoma patients. In a cross-sectional study at the end of follow-up prior to biopsy, 8 of 20 patients with a persistent HPV 16 infection had specific mCTLp against at least one of the two oncoproteins. By contrast, no specific mCTLp activity was detected in II HPV-negative patients or in 7 patients who had cleared an HPV 16 infection at the end of follow-up. However, 5 of II cervical carcinoma patients showed mCTLp activity against the E7 protein only. This study demonstrates that HPV 16 oncogene-specific mCTLp are present in women with HPV 16-positive CIN prior to any intervention. Since HPV-specific mCTLp were detected predominantly in women with high-grade lesions or invasive cervical carcinoma and not in women who cleared the virus, the role of naturally occurring mCTLp in the protection against HPV-associated cervical neoplasia remains to be established. (C) 2000 Wiley-Liss, Inc.
Databáze: OpenAIRE
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