Frequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response to therapy
| Autor: | Pietro Emiliano, Doneddu, Dario, Cocito, Fiore, Manganelli, Raffaella, Fazio, Chiara, Briani, Massimiliano, Filosto, Luana, Benedetti, Elisa, Bianchi, Stefano, Jann, Anna, Mazzeo, Giovanni, Antonini, Giuseppe, Cosentino, Girolama Alessandra, Marfia, Andrea, Cortese, Angelo Maurizio, Clerici, Marinella, Carpo, Angelo, Schenone, Gabriele, Siciliano, Marco, Luigetti, Giuseppe, Lauria, Tiziana, Rosso, Guido, Cavaletti, Ettore, Beghi, Giuseppe, Liberatore, Lucio, Santoro, Emanuele, Spina, Erdita, Peci, Stefano, Tronci, Marta, Ruiz, Stefano, Cotti Piccinelli, Elena Pinuccia, Verrengia, Luca, Gentile, Luca, Leonardi, Giorgia, Mataluni, Laura, Piccolo, Eduardo, Nobile-Orazio, Mario, Sabatelli |
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| Přispěvatelé: | Doneddu, P. E., Cocito, D., Manganelli, F., Fazio, R., Briani, C., Filosto, M., Benedetti, L., Bianchi, E., Jann, S., Mazzeo, A., Antonini, G., Cosentino, G., Marfia, G. A., Cortese, A., Clerici, A. M., Carpo, M., Schenone, A., Siciliano, G., Luigetti, M., Lauria, G., Rosso, T., Cavaletti, G., Beghi, E., Liberatore, G., Santoro, L., Spina, E., Peci, E., Tronci, S., Ruiz, M., Cotti Piccinelli, S., Verrengia, E. P., Gentile, L., Leonardi, L., Mataluni, G., Piccolo, L., Nobile-Orazio, E., Doneddu, P, Cocito, D, Manganelli, F, Fazio, R, Briani, C, Filosto, M, Benedetti, L, Bianchi, E, Jann, S, Mazzeo, A, Antonini, G, Cosentino, G, Marfia, G, Cortese, A, Clerici, A, Carpo, M, Schenone, A, Siciliano, G, Luigetti, M, Lauria, G, Rosso, T, Cavaletti, G, Beghi, E, Liberatore, G, Santoro, L, Spina, E, Peci, E, Tronci, S, Ruiz, M, Cotti Piccinelli, S, Verrengia, E, Gentile, L, Leonardi, L, Mataluni, G, Piccolo, L, Nobile-Orazio, E |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Diabetic neuropathy Comorbidity 030204 cardiovascular system & hematology Adrenal Cortex Hormone Monoclonal Gammopathy of Undetermined Significance 0302 clinical medicine Immunologic Factor Diabetic Neuropathies Adrenal Cortex Hormones 80 and over Age of Onset Chronic Inflammatory Demyelinating Child Aged 80 and over education.field_of_study diabetes Plasma Exchange Immunoglobulins Intravenous Diabetes Mellitu Middle Aged Settore MED/26 - NEUROLOGIA Psychiatry and Mental health Treatment Outcome Italy MGUS Female Intravenous Human Adult medicine.medical_specialty Adolescent Population Polyradiculoneuropathy Immunoglobulins CIDP Settore MED/26 Autoimmune Disease Autoimmune Diseases 03 medical and health sciences Young Adult Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Immunologic Factors Sex Distribution education Aged business.industry Retrospective cohort study medicine.disease Polyradiculoneuropathy Chronic Inflammatory Demyelinating CIDP neuropathy diabates Immunoglobulins Intravenou Quality of Life Surgery Diabetic Neuropathie Neurology (clinical) Age of onset business 030217 neurology & neurosurgery Monoclonal gammopathy of undetermined significance |
| Popis: | ObjectivesTo determine the prevalence of different comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and their impact on outcome, treatment choice and response.MethodsUsing a structured questionnaire, we collected information on comorbidities from 393 patients with CIDP fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society criteria included in the Italian CIDP database.ResultsOne or more comorbidities were reported by 294 patients (75%) and potentially influenced treatment choice in 192 (49%) leading to a less frequent use of corticosteroids. Response to treatment did not differ, however, from that in patients without comorbidities. Diabetes (14%), monoclonal gammopathy of undetermined significance (MGUS) (12%) and other immune disorders (16%) were significantly more frequent in patients with CIDP than expected in the general European population. Patients with diabetes had higher disability scores, worse quality of life and a less frequent treatment response compared with patients without diabetes. Patients with IgG-IgA or IgM MGUS had an older age at CIDP onset while patients with other immune disorders had a younger age at onset and were more frequently females. IgM MGUS was more frequent in patients with motor CIDP than in patients with typical CIDP.ConclusionsComorbidities are frequent in patients with CIDP and in almost 50% of them have an impact on treatment choice. Diabetes, MGUS and other immune diseases are more frequent in patients with CIDP than in the general population. Only diabetes seems, however, to have an impact on disease severity and treatment response possibly reflecting in some patients a coexisting diabetic neuropathy. |
| Databáze: | OpenAIRE |
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