Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction
| Autor: | Hadi Sharouny, Nafiseh Sheykhbahaei, Maryam Alipanahi Ramandi, Mehrdad Jafari, Maziar Motiee-Langroudi, Narges Gholizadeh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oral
medicine.medical_specialty Saliva Gastroenterology Malignant transformation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Lactate dehydrogenase medicine Carcinoma Humans General Dentistry l-lactate dehydrogenase Tumor marker Squamous Cell Carcinoma of Head and Neck business.industry Squamous cell 030206 dentistry medicine.disease Lichenoid eruptions lcsh:RK1-715 stomatognathic diseases chemistry Head and Neck Neoplasms Case-Control Studies lcsh:Dentistry 030220 oncology & carcinogenesis Lichenoid eruption Carcinoma Squamous Cell Oral and maxillofacial surgery Mouth Neoplasms Oral lichen planus Lichen planus business Lichen Planus Oral Research Article |
| Zdroj: | BMC Oral Health, Vol 20, Iss 1, Pp 1-8 (2020) BMC Oral Health |
| ISSN: | 1472-6831 |
| Popis: | Background Increased levels of lactate dehydrogenase (LDH) as a tumor marker have been reported in malignant and some premalignant oral lesions such as oral lichen planus (OLP) and oral lichenoid reactions (OLRs). This study aimed to assess the level of total LDH in the saliva and serum of patients with oral squamous cell carcinoma (OSCC), OLP and OLRs. Methods In this case–control study, the participants were divided into four groups (n = 25) of healthy controls, OLP, OLRs, and OSCC. The serum and stimulated/unstimulated salivary levels of LDH were spectrophotometrically measured using standard LDH kits (Pars Azmoun). One-way ANOVA, Chi-square test, Pearson’s correlation test, and receiver operating characteristic (ROC) analysis were applied to analyze the data. Results The serum and salivary levels of LDH in OSCC patients were significantly higher than that the corresponding values in other groups (P = 0.0001). The serum level of LDH in OLR group was significantly higher than that in the control and OLP groups (P = 0.0001), but the difference in salivary level of LDH was not significant. The ROC analysis showed that both the serum and salivary levels of LDH had significant diagnostic ability for detection of OSCC and OLRs. Significant associations were noted between the serum and salivary levels of LDH. Conclusions Patients with OSCC and OLRs had higher serum levels of LDH than OLP and control groups. Further prospective longitudinal studies are required to assess the tissue level of LDH and monitor the transformation of OLRs because they have low rate of malignant transformation compared with other oral premalignant lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink