Prenatal and early postnatal food restrictions cause changes in brain oxidative status and orexigenic/anorexigenic hormones in the offspring of rats: prevention by quercetin and kaempferol
| Autor: | Bartholomew Chukwuebuka Nwogueze, Kenneth Kelechi Anachuna, Goodies Emuesiri Moke, EE Iyare, Nkiru A. Katchy, Boluwatife Adeniyi, Benneth Ben-Azu, Cordilia Iyare |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Leptin
medicine.medical_specialty PrNFR Prenatal-food restriction PND postnatal day Offspring BMI body mass index KFAM Kaempferol DMSO dimethyl sulfoxide Biology VO vaginal opening medicine.disease_cause Article Kaempferol chemistry.chemical_compound Orexigenic Internal medicine PsNFR postnatal-food restriction medicine Ecology Evolution Behavior and Systematics lcsh:RM1-950 BPS balano-preputal separation Malondialdehyde Food restriction Ghrelin ANOVA one-way analysis of variance lcsh:Therapeutics. Pharmacology Endocrinology chemistry Oxidative stress Quercetin QCET Quercetin Animal Science and Zoology medicine.drug Hormone |
| Zdroj: | Current Research in Pharmacology and Drug Discovery Current Research in Pharmacology and Drug Discovery, Vol 1, Iss, Pp 39-52 (2020) |
| ISSN: | 2590-2571 |
| DOI: | 10.1016/j.crphar.2020.100005 |
| Popis: | Brain oxidative signaling pathways have been identified as important targets for alleviating food deprivation-induced changes in metabolic gate-ways. Previous studies have shown that prenatal and early postnatal malnutrition alters leptin and ghrelin signaling via oxidative pathways. Thus, it has been hypothesized that agents with antioxidant properties might be beneficial for the mitigation of prenatal and early postnatal food scarcity-induced oxidative damage. Quercetin and kaempferol are natural bioflavonoids with proven antioxidant properties. In this study, we evaluated their effects on prenatal maternal food consumption, maternal and pup weights, biomarkers of orexigenic and anorexigenic hormones and oxidative stress in rats. Rats were allotted into different treatment groups (n = 6) in three different experiments (prenatal, postnatal food-deprivations or both). Prenatal-food restriction (PrNFR) was induced by 50% of ad libitum accessible diet during pregnancy till parturition and postnatal-food restriction (PsNFR) was simulated by litter-enlargement to 16 pups per mother from postnatal day (PND) 2. Rats in each experiment were concurrently treated with vehicle (10 mL/kg), quercetin (50, 100 and 200 mg/kg, p.o.) or kaempferol (50, 100 and 200 mg/kg, p.o.) respectively. A third experimental group consisted of both protocols. Quercetin and kaempferol dose-dependently increased the body weights of pups exposed to PrNFR, PsNFR and PrNFR-PsNFR at PNDs 1–22 respectively. Both compounds increased maternal body weights but attenuated maternal food-intake at prenatal days 7 and 14 due by PrNFR. Quercetin and kaempferol reduced brain malondialdehyde concentrations and increased glutathione levels in PrNFR, PsNFR and PrNFR-PsNFR-exposed offspring of rats. Importantly, quercetin and kaempferol significantly (p Highlights • PrNFR and PsNFR reduce maternal and fetal weights. • Quercetine and kaempferol increase PrNFR and PsNFR-induced weight loss. • Quercetine and kaempferol attenuate PrNFR and PsNFR-induced ghrelin alteration. • Quercetine and kaempferol attenuate PrNFR and PsNFR-induced leptin alteration. • Quercetine and kaempferol reduced PrNFR and PsNFR-induced brain oxidative stress. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|