Single-Cell Squamous Carcinoma
| Autor: | Patrick M. Mulvaney, Amanda Auerbach, Elizabeth Foley, Dori Goldberg, Mary E. Maloney |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Skin Neoplasms
Cell Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Neoplasm Recurrence Text mining Risk Factors Carcinoma medicine Humans Basal cell Neoplasm Metastasis business.industry General Medicine medicine.disease Squamous carcinoma stomatognathic diseases medicine.anatomical_structure Risk variant 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Surgery Neoplasm Recurrence Local business |
| Zdroj: | Dermatologic Surgery. 42:S2-S7 |
| ISSN: | 1076-0512 |
| Popis: | There is increasing interest in establishing diagnostic and treatment guidelines for high-risk squamous cell carcinoma (SCC). Single-cell SCC has been recognized as a high-risk subtype but continues to be a less commonly reported and more poorly understood variant.To present the current literature on single-cell SCC.A review of the literature on single-cell squamous cell carcinoma.There are fewer than 100 cases of single-cell SCC in the literature. The reporting studies demonstrate an increase in the risk of metastasis compared with non-single-cell tumors. Confounding variables reported include other coexisting high-risk features: diameter2 cm, depth6 mm, and difficulty detecting single tumor cells. It is therefore unclear whether single-cell SCC is an independent risk factor for recurrence and regional spread. Studies have described use of immunostaining as a means to improve tumor detection.Single-cell SCC continues to be an underreported SCC variant. Given its apparent aggressive behavior, more studies are warranted to better understand its tumor biology and behavior and to improve patient outcomes. Based on our present knowledge, complete tumor excision with or without the aid of immunostaining and use of multidisciplinary care are recommended. |
| Databáze: | OpenAIRE |
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