The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers
| Autor: | Shirley K. Knauer, Nisintha Mahendrarajah, Oliver H. Krämer, Wynand P. Roos |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Ubiquitin-Protein Ligases Endocrinology Diabetes and Metabolism medicine.medical_treatment Immunology Breast Neoplasms SIAH2 medicine.disease_cause General Biochemistry Genetics and Molecular Biology Prostate cancer Ubiquitin medicine Animals Humans Immunology and Allergy Epithelial–mesenchymal transition Triple-negative breast cancer biology Nuclear Proteins Prostatic Neoplasms medicine.disease Cell Transformation Neoplastic Cytokine biology.protein Cancer research Female Carcinogenesis Biologie |
| Popis: | The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and SIAH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells. Here we review the current knowledge on the impact of SIAHs on breast and prostate tumorigenesis. Furthermore, we summarize how stress, hormones, and cytokines regulate SIAH1 and SIAH2 in transformed mammalian cells. |
| Databáze: | OpenAIRE |
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