OnabotulinumtoxinA is effective in patients with urinary incontinence due to neurogenic detrusor activity regardless of concomitant anticholinergic use or neurologic etiology
| Autor: | Philip Aliotta, Francisco Cruz, Karl-Dietrich Sievert, John Heesakkers, Wayne Lam, David A. Ginsberg, Angelo E. Gousse, Brenda Jenkins, Mitchell F. Brin, Sender Herschorn, Cornelia Haag-Molkenteller, V. Keppenne, Catherine Thompson |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis medicine.drug_class Urinary Bladder Urology Urinary incontinence DCN PAC - Perception action and control Spinal cord injury Injections Intramuscular Cholinergic Antagonists Double-Blind Method Botulinum toxin OnabotulinumtoxinA Anticholinergic medicine Humans Pharmacology (medical) Botulinum Toxins Type A Urinary Bladder Neurogenic Spinal Cord Injuries Original Research Medicine(all) Urinary bladder business.industry Urinary Bladder Overactive Multiple sclerosis General Medicine Middle Aged medicine.disease Urodynamics medicine.anatomical_structure Treatment Outcome Neuromuscular Agents Concomitant Anesthesia Etiology Female medicine.symptom business medicine.drug |
| Zdroj: | Advances in Therapy, 30, 819-33 Advances in Therapy Advances in Therapy, 30, 9, pp. 819-33 |
| ISSN: | 0741-238X |
| Popis: | Item does not contain fulltext INTRODUCTION: To evaluate the efficacy and safety of onabotulinumtoxinA for the treatment of neurogenic detrusor overactivity (NDO) in subpopulations of etiology (multiple sclerosis [MS] or spinal cord injury [SCI]) and concomitant anticholinergics (use/non-use). METHODS: Data were pooled from two double-blind, placebo-controlled, pivotal, phase 3 studies including a total of 691 patients with >/= 14 urinary incontinence (UI) episodes/week due to MS (n = 381) or SCI (n = 310). Patients received intradetrusor injections of onabotulinumtoxinA 200U (n = 227), 300U (n = 223), or placebo (n = 241). Change from baseline at week 6 in UI episodes/week (primary endpoint), urodynamics, quality of life (QOL), and adverse events (AEs) were assessed. RESULTS: Significant and similar reductions in UI episodes were observed regardless of etiology or anticholinergic use: at week 6, mean weekly decreases of -22.6 and -19.6 were seen in MS and SCI patients, respectively, and -20.3 and -22.5 in anticholinergic users and non-users, respectively, treated with onabotulinumtoxinA 200U. The 300U dose did not add to the clinical efficacy in any subpopulation. Similar proportions of patients achieved >/= 50% or 100% reductions in UI episodes in all subgroups. Improvements in maximum cystometric capacity, maximum detrusor pressure during first involuntary detrusor contraction, and QOL were significant in both etiologies and were independent of anticholinergic use. The most common AEs in all groups were urinary tract infection and urinary retention. CONCLUSION: Regardless of concomitant anticholinergic use or etiology, onabotulinumtoxinA significantly improved UI symptoms, urodynamics, and QOL in patients with UI due to NDO. OnabotulinumtoxinA was well tolerated in all groups. |
| Databáze: | OpenAIRE |
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