Cross-sectional analysis of retrospective case series of hospitalisations for gastropathy caused by non-steroidal anti-inflammatory treatment: risk factors and gastroprotection use
| Autor: | Manuel Koninckx Cañada, José Luis Marco Garbayo, María Teresa Faus Soler, Rosa Fuster Torres, Mar Moncho Escrivà, Isabel Pérez Castelló |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Risk management plan medicine.drug_class business.industry Cross-sectional study Proton-pump inhibitor Retrospective cohort study Metamizole medicine.disease Surgery 03 medical and health sciences 0302 clinical medicine Concomitant Internal medicine Pharmacovigilance medicine Original Article 030211 gastroenterology & hepatology 030212 general & internal medicine Upper gastrointestinal bleeding General Pharmacology Toxicology and Pharmaceutics business medicine.drug |
| Zdroj: | European Journal of Hospital Pharmacy. 24:355-360 |
| ISSN: | 2047-9964 2047-9956 |
| Popis: | Objectives To analyse the risk factors of gastropathy caused by using non-steroidal anti-inflammatory drugs (NSAIDs) in detected hospital admissions and to analyse the use of gastroprotective treatment concerning these risk factors. Methods A retrospective observational study was carried out in the framework of an integral risk management plan of drugs and proactive pharmacovigilance of hospital admissions for NSAID-induced gastropathy occurring between 2011 and 2015. Cases were identified after reviewing the ICD-9 codes related to NSAID-induced gastropathy in hospital discharge reports. Various biometric, clinical and pharmacotherapeutic variables of each patient were registered. The gastroprotective criteria set out in the therapeutic decision algorithm of the Valencian Health System were followed. Results 62 hospital admissions for NSAID-induced gastropathy were detected. The mean length of stay was 5.3±3.8 days. Ibuprofen was the most prevalent NSAID (28 cases, 45.2%). 24 cases (38.7%) took NSAIDs in the week before hospitalisation. The prevalence of relevant risk factors for gastropathy were age >60 years (37 cases, 59.7%), concomitant medication (24 cases, 38.7%) and a history of peptic ulcer (9 cases, 14.5%). 41 patients (66.1%) met gastroprotective major criteria, 18 of whom (43.9%) were using a proton pump inhibitor following a prevention plan. Conclusions In this study all relevant gastroprotective criteria were associated with the use of gastroprotection in detected hospital admissions for NSAID-induced gastropathy. However, a lack of gastroprotection was observed in a large number of detected cases with the criteria to use it. The feedback of our results to health area agents can serve to reinforce the safe use of NSAIDs. |
| Databáze: | OpenAIRE |
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