Supplementary Text, Supplementary Figures 1 through 13, Supplementary Methods from Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma

Autor: Patrick Tan, John Connolly, Jeeyun Lee, Dennis Kappei, Bin Tean Teh, Steven G. Rozen, Wai Keong Wong, Kyoung-Mee Kim, Khee Chee Soo, Hock Soo Ong, Weng Hoong Chan, Pierce K.H. Chow, Wei Peng Yong, Khay Guan Yeoh, Sun Young Rha, Hassan Ashktorab, Duane Smoot, Apinya Jusakul, Alvin Ng, Cedric Chuan Young Ng, Erna Gondo Santoso, Angie Tan Lay Keng, Su Ting Tay, Minghui Lee, Xuewen Ong, Xiaosai Yao, Tannistha Nandi, Joyce Suling Lin, Wen Fong Ooi, Qianqao Tang, Ai Ping Lee Lim, Yan Shan Leong, Chang Xu, Shenli Zhang, Jeffrey Jun Ting Kwok, Nisha Padmanabhan, Manjie Xing, Aditi Qamra
Rok vydání: 2023
DOI: 10.1158/2159-8290.22531775
Popis: Supplementary text S1. Supplementary Figure 1: Chromatin Profiles of Primary GC. Supplementary Figure 2: Epithelial features of GC promoters. Supplementary Figure 3: GC Somatic Promoter Features. Supplementary Figure 4: Association of Somatic Promoters with Gene Expression in GC and Other Tumor Types. Supplementary Figure 5: Changes in DNA methylation at CpG island containing promoters. Supplementary Figure 6: Expression distribution of alternative and canonical isoforms. Supplementary Figure 7: Characterization of RASA3 Isoform. Supplementary Figure 8: Characterization of MET Isoforms. Supplementary Figure 9: Immunogenicity of N-terminal peptides. Supplementary Figure 10: Immunogenicity Assay and Nanostring Profiling. Supplementary Figure 11: Functional Assessment of Peptide Immunogenicity. Supplementary Figure 12: EZH2 Inhibition. Supplementary Figure 13: Unannotated somatic promoters.
Databáze: OpenAIRE