Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanized Brazilian state
| Autor: | Talita Émile Ribeiro Adelino, Chislene Pereira Vanelli, Ricardo José de Paula Souza e Guimarães, Elba Regina Sampaio de Lemos, Igor Rosa Meurer, José Otávio do Amaral Corrêa, Ana Íris de Lima Duré, Marcio Roberto Silva, Marcos Vieira Silva, Tatiana Rozental, Alana Vitor Barbosa da Costa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Risk analysis Livestock Estudos Soroepidemiol?gicos 030106 microbiology Zoonoses Bacterianas Q fever Dengue fever 03 medical and health sciences 0302 clinical medicine Risk Factors Seroepidemiologic Studies Environmental health Zoonoses medicine Seroprevalence Animals Humans 030212 general & internal medicine Minas Gerais (MG) Risk factor Coxiella burnetii / isolamento & purifica??o biology business.industry Zoonosis Public Health Environmental and Occupational Health Febre Q / veterin?ria General Medicine Coxiella burnetii biology.organism_classification medicine.disease Antibodies Bacterial Infectious Diseases T?cnica Indireta de Fluoresc?ncia para Anticorpo / m?todos Parasitology Cria??o de Animais Dom?sticos business Q Fever Brazil Rea??o em Cadeia da Polimerase em Tempo Real / m?todos |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC |
| Popis: | Federal University of Juiz de Fora. Faculty of Pharmacy. Juiz de Fora, MG, Brazil. Embrapa Dairy Cattle. Juiz de Fora, MG, Brazil Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil. Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil. Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil. Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil. Suprema. Faculty of Medical Sciences and Health of Juiz de Fora. Juiz de Fora, MG, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Geoprocessamento. Ananindeua, PA, Brasil. Oswaldo Cruz Foundation. Laboratory of Hantaviruses and Rickettsiosis. Rio de Janeiro, RJ, Brazil. Oswaldo Cruz Foundation. Laboratory of Hantaviruses and Rickettsiosis. Rio de Janeiro, RJ, Brazil. Federal University of Juiz de Fora. Faculty of Pharmacy. Juiz de Fora, MG, Brazil. Background: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state. Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Risk factors for infections and spatial clusters for both C. burnetii-seropositive individuals and livestock concentration were evaluated. Results: We found that 21 samples (4.8%; 95% CI 3.0 to 7.2%) were reactive for at least one class of anti-C. burnetii antibodies (titer of ?64), with rural residence (p=0.036) being a risk factor. Also, two spatial clusters of seropositivity were found within a significant area by Scan, and a probable relationship between the Scan result and the livestock concentration by area was found. Conclusions: Seropositive individuals were associated with rural residence, with a likely relationship with the livestock concentration. Thus, this study establishes baseline figures for C. burnetii seroprevalence in humans in a state of Brazil, allowing the monitoring of trends and setting of control targets, as well as more representative longitudinal and risk analysis studies. |
| Databáze: | OpenAIRE |
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