COINFECTION BY HEPATITIS B AND HEPATITIS DELTA VIRUSES: MOLECULAR BIOLOGY OF PATHOGENS AND PROSPECTS OF PHARMACOTHERAPY
| Autor: | Ya. R. Sepiashvili, E S Malova, T. A. Slavyanskaya, R I Sepiashvili, I P Balmasova |
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| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
hepatitis b virus viruses Medicine (miscellaneous) Biology Microbiology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy hepatitis delta virus antiviral therapy medicine virus diseases General Medicine Hepatitis B biochemical phenomena metabolism and nutrition medicine.disease Virology digestive system diseases coinfection QR1-502 030104 developmental biology Coinfection 030211 gastroenterology & hepatology Hepatitis D virus molecular biology of viruses |
| Zdroj: | Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 0, Iss 2, Pp 95-102 (2018) |
| ISSN: | 2686-7613 0372-9311 |
| Popis: | Hepatitis delta virus (HDV) is a defective virus and obligate companion of hepatitis B virus (HBV). The clinical significance of HDV and HBV coinfection is associated with more severe forms of acute or chronic viral hepatitis, a higher risk of developing liver cirrhosis and hepatocellular carcinoma compared to BGV-monoinfection. Current knowledge of the molecular biology of pathogens confirms the existence of a very complex relationship between the HBV, HDV, infected hepatocytes and cells of the immune system. Despite the fact that HBV viremia can now be controlled by using nucleoside analogues in the majority of patients, the problem of treating HDV and HBV coinfection is far from being resolved. Fundamental studies in recent years have led to significant progress in understanding the biology of HDV and provide the basis for the development and introduction into clinical practice highly effective antiviral drugs. |
| Databáze: | OpenAIRE |
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