Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL/J mice
| Autor: | Raymond J. Connolly, N. Chandler, Stanley Jacobson, Theoharis C. Theoharides, Pamela Esposito |
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| Rok vydání: | 2002 |
| Předmět: |
Encephalomyelitis
Autoimmune Experimental Time Factors Proteolipid protein 1 Encephalomyelitis Immunology Central nervous system Mice Inbred Strains Capillary Permeability Mice Behavioral Neuroscience Stress Physiological immune system diseases Parenchyma medicine Animals Chronic stress Endocrine and Autonomic Systems business.industry Incidence Multiple sclerosis Technetium medicine.disease Extravasation nervous system diseases medicine.anatomical_structure Blood-Brain Barrier Acute Disease Female Disease Susceptibility business Infiltration (medical) |
| Zdroj: | Brain, Behavior, and Immunity. 16:757-763 |
| ISSN: | 0889-1591 |
| DOI: | 10.1016/s0889-1591(02)00028-4 |
| Popis: | Experimental allergic encephalomyelitis (EAE) is a murine model of multiple sclerosis (MS), an inflammatory condition of the central nervous system (CNS) resulting in focal demyelination due to the infiltration of sensitized T-leukocytes through the blood-brain barrier (BBB). While chronic stress models have been shown to reduce EAE, acute emotional stress appears to exacerbate many neuroin-flammatory disorders, including remitting-relapsing MS. This is the only study to our knowledge that examined the effect of acute stress on EAE. Immobilization of SJL/J mice for 60 min, at days 2 and 3 post-inoculation with proteolipid protein (PLP), resulted in symptoms of EAE becoming apparent 4 days earlier than in control mice. The possibility that this effect could be due to increased BBB permeability was investigated by detecting 99Technetium (99Tc) gluceptate extravasation into brain parenchyma post-stress utilizing a gamma camera. There was 80% increase in BBB permeability after 60 min of acute immobilization stress as compared to controls. These findings may help explain the earlier onset of EAE symptoms. |
| Databáze: | OpenAIRE |
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