Help wanted: helper NLRs and plant immune responses
| Autor: | Svenja C. Saile, Farid El Kasmi, Lance M. Jubic, Jeffery L. Dangl, Oliver J. Furzer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Fungal protein Effector Plant Immunity NLR Proteins Plant Science Biology Plants 01 natural sciences Cell biology Fungal Proteins 03 medical and health sciences 030104 developmental biology Immune system Animals Receptor Intracellular Function (biology) 010606 plant biology & botany Disease Resistance Plant Diseases Plant Proteins |
| Zdroj: | Current opinion in plant biology. 50 |
| ISSN: | 1879-0356 |
| Popis: | Plant nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins function as intracellular receptors in response to pathogens and activate effector-triggered immune responses (ETI). The activation of some sensor NLRs (sNLR) by their corresponding pathogen effector is well studied. However, the mechanisms by which the recently defined helper NLRs (hNLR) function to transduce sNLR activation into ETI-associated cell death and disease resistance remains poorly understood. We briefly summarize recent examples of sNLR activation and we then focus on hNLR requirements in sNLR-initiated immune responses. We further discuss how shared sequence homology with fungal self-incompatibility proteins and the mammalian mixed lineage kinase domain like pseudokinase (MLKL) proteins informs a plausible model for the structure and function of an ancient clade of plant hNLRs, called RNLs. |
| Databáze: | OpenAIRE |
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