Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro
| Autor: | Anna Tomczak, Wieslaw Oleszek, Beata Olas, Barbara Wachowicz, Anna Stochmal, Joachim Erler |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Platelets Male Antioxidant medicine.medical_treatment Resveratrol Antioxidants Hemostatics chemistry.chemical_compound Phenols Superoxides Photinia Stilbenes medicine Yucca Humans Platelet Vitis Food science Flavonoids biology Chemistry Plant Extracts Thrombin food and beverages Polyphenols Hematology General Medicine biology.organism_classification Platelet Activation Biochemistry Polyphenol visual_art Seeds visual_art.visual_art_medium Aronia melanocarpa Plant Bark Bark Female Aronia Collagen Platelet Aggregation Inhibitors |
| Zdroj: | Platelets. 19(1) |
| ISSN: | 1369-1635 |
| Popis: | The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and anti-platelet commercial monomeric polyphenol-resveratrol. The effects of extracts on platelet adhesion to collagen, collagen-induced platelet aggregation and on the production of O2-* in resting platelets and platelets stimulated by a strong platelet agonist-thrombin were studied. The in vitro experiments have shown that all three tested extracts (5-50 microg/ml) rich in polyphenols reduce platelet adhesion, aggregation and generation of O2-* in blood platelets. Comparative studies indicate that all three plant extracts were found to be more reactive in reduction of platelet processes than the solution of pure resveratrol. The tested extracts due to their anti-platelet effects may play an important role as components of human diet in prevention of cardiovascular or inflammatory diseases, where blood platelets are involved. |
| Databáze: | OpenAIRE |
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