Continuity resection of the mandible after ameloblastoma - feasibility of oral rehabilitation with rhBMP-2 associated to bovine xenograft followed by implant installation
| Autor: | Liogi Iwaki Filho, Lilian Cristina Vessoni Iwaki, Giordano Bruno de Oliveira Marson, Diogo de Vasconcelos Macedo, Elen de Souza Tolentino, Rômulo Maciel Lustosa, Paulo Norberto Hasse |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Denture Partial medicine.medical_treatment Tumor resection Dentistry Bone Morphogenetic Protein 2 Osseointegration Resection Ameloblastoma Transforming Growth Factor beta Absorbable Implants medicine Animals Humans Mandibular reconstruction Dental Implants Minerals Rehabilitation Bone Transplantation business.industry Dental Implantation Endosseous Mandible Membranes Artificial Surgical Mesh medicine.disease Recombinant Proteins Surgery Mandibular Neoplasms Otorhinolaryngology Feasibility Studies Heterografts Cattle Implant Collagen Dental Prosthesis Implant-Supported Oral Surgery Mandibular Reconstruction business Follow-Up Studies |
| Zdroj: | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 43(8) |
| ISSN: | 1878-4119 |
| Popis: | Recombinant human morphogenetic protein (rhBMP) is a graft alternative for extensive mandibular reconstruction after tumor resections. However, the feasibility of rhBMP-2 to receive osseointegrated implants and prosthetic rehabilitation has been rarely reported. This study reports on a case of an extensive solid ameloblastoma along the mandibular body. The treatment consisted of resection followed by off-label use of rhBMP type 2 associated with bovine bone xenograft. Eleven months postoperatively, the patient was prosthetically rehabilitated with dental implants, without evidence of resorption or complications. The literature on mandibular reconstructions using rhBMP and their feasibility for future osseointegrated implant placement was also reviewed. Based on the presented case, the association between rhBMP-2 and a bovine bone xenograft could be considered a feasible option for the reconstruction and rehabilitation of large mandibular defects after tumor resection. According to the literature, the use of rhBMP as a graft material is encouraging, with good clinical outcome. However, there are no long-term studies demonstrating success and survival rates of implants placed in these grafts. Future investigations will be required to ascertain the long-term survival of implants in areas grafted with rhBMP. Also, there is a lack of information regarding the prosthetic rehabilitation of these patients. |
| Databáze: | OpenAIRE |
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