Differentiation of Donor-Derived Cells Into Microglia After Umbilical Cord Blood Stem Cell Transplantation
| Autor: | Kazuya Takahashi, Saori Munemoto, Hirohito Yamazaki, Ichiro Nozaki, Yumiko Kakuda, Masahito Yamada |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cord Blood Stem Cell Transplantation Biology Lymphoma T-Cell Umbilical cord Pathology and Forensic Medicine Umbilical cord blood Cellular and Molecular Neuroscience Fatal Outcome Cell Movement Parenchyma medicine Humans Progenitor cell Glia limitans Stem cell Microglia Brief Report Brain Cell Differentiation General Medicine Middle Aged Cord lining medicine.anatomical_structure Neurology Differentiation Female Neurology (clinical) Progenitor |
| Zdroj: | Journal of Neuropathology and Experimental Neurology |
| ISSN: | 1554-6578 0022-3069 |
| DOI: | 10.1097/nen.0000000000000234 |
| Popis: | Recent studies have indicated that microglia originate from immature progenitors in the yolk sac. After birth, microglial populations are maintained under normal conditions via self-renewal without the need to recruit monocyte-derived microglial precursors. Peripheral cell invasion of the brain parenchyma can only occur with disruption of the blood-brain barrier. Here, we report an autopsy case of an umbilical cord blood transplant recipient in whom cells derived from the donor blood differentiated into ramified microglia in the recipient brain parenchyma. Although the blood-brain barrier and glia limitans seemed to prevent invasion of these donor-derived cells, most of the invading donor-derived ramified cells were maintained in the cerebral cortex. This result suggests that invasion of donor-derived cells occurs through the pial membrane. Copyright © 2015 by the American Association of Neuropathologists, Inc. |
| Databáze: | OpenAIRE |
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