Novel platinum(IV) complexes induce rapid tumor cell death in vitro
| Autor: | Vladimir Trajkovic, Vesna M. Djinović, Marija Mostarica Stojković, Goran N. Kaludjerović, Djordje Miljković, Miljana Momčilović, Tibor J. Sabo |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Organoplatinum Compounds Fibrosarcoma Tumor Cell Necrosis cisplatin Apoptosis Biology Astrocytoma 010402 general chemistry 01 natural sciences necrosis 03 medical and health sciences Mice Necrosis medicine Tumor Cells Cultured Cytotoxic T cell oxidative stress Animals Humans Cytotoxicity 030304 developmental biology Platinum Cisplatin 0303 health sciences Brain Neoplasms apoptosis Biological activity medicine.disease In vitro 3. Good health 0104 chemical sciences Oxidative Stress Oncology platinum(IV) Cancer research medicine.drug |
| Zdroj: | International Journal of Cancer |
| ISSN: | 0020-7136 |
| Popis: | The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. (C) 2005 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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