Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy
| Autor: | Carlos Simón, José María Martínez-Jabaloyas, Marcos Meseguer, Antonio Pellicer, José Remohí, Nicolás Garrido, Manuel Gil-Salom |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Semen urologic and male genital diseases Intracytoplasmic sperm injection Pregnancy Neoplasms Testis medicine Humans Sperm Injections Intracytoplasmic reproductive and urinary physiology Testicular cancer Retrospective Studies Cryopreservation Azoospermia urogenital system business.industry Rehabilitation Obstetrics and Gynecology Oligospermia Embryo Transfer medicine.disease Sperm Chemotherapy regimen Testicular sperm extraction Surgery Radiation therapy Treatment Outcome Reproductive Medicine Sperm Motility Tissue and Organ Harvesting Female business Semen Preservation |
| Zdroj: | Human Reproduction. 18:1281-1285 |
| ISSN: | 1460-2350 |
| Popis: | BACKGROUND: Patients persistently azoospermic after chemotherapy have been considered traditionally as sterile unless sperm was frozen before therapy. Recent advances during the last decade combining testicular sperm extraction (TESE) and ICSI in patients with non-obstructive azoospermia allow these males to father their own genetic offspring. METHODS: A retrospective study was conducted of 12 patients with non-obstructive azoospermia after chemotherapy undergoing TESE between 1995 and 2002. Cancer type and anti-neoplastic treatments were recorded, together with maximum testicular volume, serum FSH levels and testicular histopathology. When TESE was successful, spermatozoa were cryopreserved for performing ICSI later. RESULTS: In five patients (41.6%) motile spermatozoa for cryopreservation and ICSI were retrieved. Four of them had received chemotherapy for testicular cancer, and one had been treated by chemotherapy/radiotherapy for Hodgkin’s disease. Clinical and histological parameters were unable to predict with certainty TESE outcome in an individual patient. Eight ICSI cycles were performed on five couples and one pregnancy was obtained which resulted in the delivery of a healthy girl. CONCLUSION: Some patients with permanent azoospermia after chemotherapy can be successfully treated by TESE‐ICSI. This procedure, however, may have potential genetic risks. Therefore, freezing semen before starting gonadotoxic therapy is the strategy of choice, and patients should be counselled accordingly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|