Comparison of cardiac autonomic function across complete glycaemic spectrum
| Autor: | Rajathi, Rajendran, Vivek Kumar, Sharma, Kolar Vishwanath, Vinod, Ramesh, Ananthakrishnan, Hanumanthappa, Nandeesha, Senthil Kumar, Subramanian |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Basic and Clinical Physiology and Pharmacology. 34:329-336 |
| ISSN: | 2191-0286 0792-6855 |
| DOI: | 10.1515/jbcpp-2022-0053 |
| Popis: | Objectives Autonomic imbalance is attributed as key mechanism altering metabolic regulation in diabetes mellitus. In view of controversial reports on autonomic function in FDRD and prediabetes, we aimed to assess and compare the autonomic function across the complete glycaemic spectrum in Indian population. Methods Short term heart rate variability and cardiac autonomic reactivity tests – blood pressure and heart rate response to orthostatic tolerance and deep breathing exercise, and diastolic response to isometric handgrip exercise were recorded in normoglycemic apparently healthy individual, normoglycemic first degree relatives of diabetes, prediabetes and diabetes individuals. Results Resting heart rate is significantly higher in FDRD, prediabetes and diabetes as compared to controls (control Conclusions Autonomic dysfunction is observed even in first degree relatives of diabetes. Autonomic dysfunction increases as we move along the glycaemic spectrum (control |
| Databáze: | OpenAIRE |
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