Geraniol attenuates hydrogen peroxide-induced liver fatty acid alterations in male rats
| Autor: | Abdurrauf Yüce, Zafer Sahin, Ahmet Özkaya, Sait Çelik, Ahmet Orhan Görgülü |
|---|---|
| Přispěvatelé: | Uşak Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant Geraniol medicine.medical_treatment hydrogen peroxide Toxicology liver fatty acids 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine oxidative stress Pharmacology (medical) lcsh:Miscellaneous systems and treatments Original Research Pharmacology chemistry.chemical_classification biology Glutathione peroxidase lcsh:RM1-950 Fatty acid Glutathione Malondialdehyde lcsh:RZ409.7-999 030104 developmental biology Endocrinology lcsh:Therapeutics. Pharmacology Complementary and alternative medicine chemistry Biochemistry Catalase biology.protein Corn oil |
| Zdroj: | Journal of Intercultural Ethnopharmacology, Vol 6, Iss 1, Pp 29-35 (2017) Journal of Intercultural Ethnopharmacology |
| ISSN: | 2146-8397 |
| Popis: | Background: Hydrogen peroxide (H2O2) is an oxidant agent and this molecule naturally occurs in the body as a product of aerobic metabolism. Geraniol is a plant-derived natural antioxidant. Aim of the present study was to determine the role of geraniol on hepatic fatty acids alterations following H2O2-induced oxidative stress in male rats. Methods: After randomization, male wistar rats were divided into four groups (n=7 each group). Geraniol (50 mg/kg, dissolved in corn oil) and H2O2 (16 mg/kg, dissolved in distilled water) were administered by an intraperitoneal injection. Administrations were performed during 30 days with one day interval. Results: Administration of H2O2 resulted with a significant increase in malondialdehyde and a significant decrease in glutathione peroxidase and glutathione level; geraniol restored its effects on liver. However, hepatic catalase activities were significantly higher in H2O2, geraniol and geraniol+H2O2 groups than control group. The ratio of hepatic total saturated fatty acids increased in H2O2-treated animals compared with control. In addition, hepatic total unsaturated fatty acids reduced in H2O2 group compared with control. The percentages of both hepatic total saturated and unsaturated fatty acids werent different between geraniol+H2O2 and control groups. Conclusions: H2O2-induced oxidative stress may affect fatty acids composition in liver and body. Geraniol can partly restore oxidative hepatic damage because it cannot completely reverse the H2O2-induced increase in hepatic catalase activities. Moreover, this natural compound can regulate hepatic total saturated and unsaturated fatty acids percentages against H2O2-induced alterations. [J Complement Med Res 2017; 6(1.000): 29-35] |
| Databáze: | OpenAIRE |
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