Determinants associated with viable genital or rectal Chlamydia trachomatis bacterial load (FemCure)
| Autor: | Hannelore M Götz, Kevin J. H. Janssen, Petra F. G. Wolffs, Maarten F. Schim van der Loeff, Nicole H. T. M. Dukers-Muijrers, Christian J. P. A. Hoebe, Sylvia M. Bruisten, Henry J. C. de Vries, Titia Heijman |
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| Přispěvatelé: | Public Health, RS: CAPHRI - R4 - Health Inequities and Societal Participation, MUMC+: DA MMI Toegelatenen (9), Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Moleculaire dia (9), MUMC+: DA MMI Management (9), Sociale Geneeskunde, Health promotion |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Vaginal discharge
medicine.medical_specialty TRANSMISSION media_common.quotation_subject Dermatology medicine.disease_cause DIAGNOSIS Urination 03 medical and health sciences 0302 clinical medicine Lower abdominal pain Blood loss SDG 3 - Good Health and Well-being INFECTION medicine Sex organ 030212 general & internal medicine Rectal symptoms media_common 0303 health sciences 030306 microbiology Genitourinary system business.industry Obstetrics WOMEN MEN Infectious Diseases SEX NEISSERIA-GONORRHOEAE medicine.symptom business Chlamydia trachomatis |
| Zdroj: | Sexually Transmitted Infections, 98(1), 17-22. BMJ Publishing Group |
| ISSN: | 1368-4973 |
| Popis: | BackgroundChlamydia trachomatis (CT) is routinely diagnosed by nucleic acid amplification tests (NAATs), which are unable to distinguish between nucleic acids from viable and non-viable CT organisms.ObjectivesWe applied our recently developed sensitive PCR (viability PCR) technique to measure viable bacterial CT load and explore associated determinants in 524 women attending Dutch sexual health centres (STI clinics), and who had genital or rectal CT.MethodsWe included women participating in the FemCure study (Netherlands, 2016–2017). At the enrolment visit (pre-treatment), 524 were NAAT positive (n=411 had genital and rectal CT, n=88 had genital CT only and n=25 had rectal CT only). We assessed viable rectal and viable genital load using V-PCR. We presented mean load (range 0 (non-viable) to 6.5 log10 CT/mL) and explored potential associations with urogenital symptoms (coital lower abdominal pain, coital blood loss, intermenstrual bleeding, altered vaginal discharge, painful or frequent micturition), rectal symptoms (discharge, pain, blood loss), other anatomical site infection and sociodemographics using multivariable regression analyses.ResultsIn genital (n=499) CT NAAT-positive women, the mean viable load was 3.5 log10 CT/mL (SD 1.6). Genital viable load was independently associated with urogenital symptoms—especially altered vaginal discharge (Beta=0.35, p=0.012) and with concurrent rectal CT (aBeta=1.79; p10 CT/mL (vs 3.3 in women without symptoms). Of 436 rectal CT NAAT-positive women, the mean rectal viable load was 2.2 log10 CT/mL (SD 2.0); rectal symptoms were reported by 2.5% (n=11) and not associated with rectal viable load.ConclusionAmong women diagnosed with CT in an outpatient clinical setting, viable genital CT load was higher in those reporting urogenital symptoms, but the difference was small. Viable genital load was substantially higher when women also had a concurrent rectal CT.Trial registration numberClinicalTrials.gov NCT02694497. |
| Databáze: | OpenAIRE |
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