Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: Tissue microarray analysis
| Autor: | David E. Cohn, Nilsa C. Ramirez, Jeffrey M. Fowler, Nicole Kelbick, Carl Morrison, Inbar Ben-Shachar, James Pavelka |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Adolescent medicine.drug_class medicine.disease_cause Sensitivity and Specificity Aromatase Organ Culture Techniques Biomarkers Tumor medicine Humans Receptor Aged Neoplasm Staging Probability Aged 80 and over Analysis of Variance Chi-Square Distribution Tissue microarray biology business.industry Endometrial cancer Membrane Proteins Obstetrics and Gynecology Middle Aged Microarray Analysis Prognosis medicine.disease Immunohistochemistry Endometrial Neoplasms Logistic Models Receptors Estrogen Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Estrogen Hormone receptor Case-Control Studies biology.protein Cancer research Female Receptors Progesterone Carcinogenesis business Carcinoma Endometrioid |
| Zdroj: | American Journal of Obstetrics and Gynecology. 192:1262-1271 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2005.01.009 |
| Popis: | The objective of this study was to compare the prevalence of cyclooxygenase-2 (COX-2), aromatase, and hormone receptor immunohistochemical (IHC) expression to well defined clinical-pathologic prognostic factors in a large group of surgically staged endometrial cancer patients.A tissue microarray (TMA) was constructed from 336 separate specimens of endometrial cancer. IHC was performed for estrogen (ER) and progesterone (PR) receptor, COX-2, COX-1, and aromatase.The majority of tumors expressed COX-2 (59%) and aromatase (65%). COX-2 staining significantly correlated with aromatase expression ( P.014) but did not correlate with ER and PR. COX-2 expression was correlated with worsening histologic grade ( P.026) and approached statistical significance for deep myometrial invasion ( P.055). After applying multivariate analysis, no single IHC or combination of IHCs correlated with intrauterine poor prognostic factors or advanced stage. Only myometrial invasion50% (OR 6.98, P.001) and nonendometrioid histology (OR 4.933, P.001) were predictive of advanced stage after multivariate analysis.COX-2 and aromatase are expressed in the majority of endometrial cancer patients. COX-2 expression was not associated with the great majority of surgical-pathologic prognostic factors. COX-2 expression did significantly correlate with aromatase expression, suggesting that intratumoral production of estrogen in endometrial cancer may be an important mechanism in tumorigenesis. |
| Databáze: | OpenAIRE |
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