Unraveling the Role of Angiogenesis in Cancer Ecosystems
| Autor: | Oriol Casanovas, Iratxe Zuazo-Gaztelu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Stromal cell Angiogenesis Review Biology lcsh:RC254-282 vasculogenesis Neovascularization angiogenesis 03 medical and health sciences 0302 clinical medicine Vasculogenesis Intussusception (blood vessel growth) medicine sprouting angiogenesis Vasculogenic mimicry Càncer vasculogenic mimicry Cancer intussusception Sprouting angiogenesis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Angiogènesi antiangiogenics 030104 developmental biology angiogenic tumor ecosystem Oncology 030220 oncology & carcinogenesis Cancer research medicine.symptom |
| Zdroj: | Frontiers in Oncology, Vol 8 (2018) Dipòsit Digital de la UB Universidad de Barcelona Frontiers in Oncology Recercat. Dipósit de la Recerca de Catalunya instname |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2018.00248 |
| Popis: | Activation of the tumor and stromal cell-driven angiogenic program is one of the first requirements in the tumor ecosystem for growth and dissemination. The understanding of the dynamic angiogenic tumor ecosystem has rapidly evolved over the last decades. Beginning with the canonical sprouting angiogenesis, followed by vasculogenesis and intussusception, and finishing with vasculogenic mimicry, the need for different neovascularization mechanisms is further explored. In addition, an overview of the orchestration of angiogenesis within the tumor ecosystem cellular and molecular components is provided. Clinical evidence has demonstrated the effectiveness of traditional vessel-directed antiangiogenics, stressing on the important role of angiogenesis in tumor establishment, dissemination, and growth. Particular focus is placed on the interaction between tumor cells and their surrounding ecosystem, which is now regarded as a promising target for the development of new antiangiogenics. |
| Databáze: | OpenAIRE |
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