Tumor-Resident CD8+ T-cell: The Critical Catalyst in IL-12-Mediated Reversal of Tumor Immune Suppression
| Autor: | Nejat K. Egilmez, Mehmet O. Kilinc |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cytotoxicity
Immunologic T cell Immunology CD8-Positive T-Lymphocytes Biology Lymphocytes Tumor-Infiltrating Immune system Neoplasms medicine Animals Humans Immunology and Allergy Cytotoxic T cell Tumor microenvironment General Medicine Interleukin-12 CTL medicine.anatomical_structure Tumor Escape Interleukin 12 Cancer research Immunotherapy Immunologic Memory CD8 |
| Zdroj: | Archivum Immunologiae et Therapiae Experimentalis. 58:399-405 |
| ISSN: | 1661-4917 0004-069X |
| Popis: | Tumor-resident T cells display a functionally impaired effector/memory (Tem) phenotype. Sustained intratumoral administration of IL-12, on the other hand, can restore cytolytic function to pre-existing CD8+ Tem, resulting in effective tumor kill. Whereas cytotoxic T lymphocytes (CTL) are generally assumed to mediate tumor regression via direct tumor cytotoxicity, recent work revealed that activated CD8+ Tem mobilize a systemic, multi-component effector cascade that includes both innate and adaptive immune mechanisms. Here we summarize these mechanisms, review how tumor-resident CD8+ Tem orchestrate this cascade and discuss the potential clinical implications of these findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink