Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

Autor: Nguyen Thi Thanh Thao, Peter C. McMinn, Tang Chi Thuong, Mary Jane Cardosa, Nguyen Thi Kim Tien, David Perera, Phan Van Tu, Ooi Mong How, Khanh Huu Truong
Rok vydání: 2007
Předmět:
Microbiology (medical)
Adolescent
Epidemiology
viruses
viral encephalitis
lcsh:Medicine
medicine.disease_cause
Coxsackievirus a16
Hand-foot-and-mouth disease
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Cell Line
Tumor
Chlorocebus aethiops
medicine
Enterovirus 71
Animals
Humans
lcsh:RC109-216
Child
Vero Cells
enterovirus 71
Phylogeny
030304 developmental biology
0303 health sciences
biology
Reverse Transcriptase Polymerase Chain Reaction
030306 microbiology
Research
Viral encephalitis
lcsh:R
virus diseases
biochemical phenomena
metabolism
and nutrition
medicine.disease
biology.organism_classification
viral skin diseases
Throat swab
Virology
Ho chi minh
Enterovirus A
Human
3. Good health
Infectious Diseases
Vietnam
Enterovirus
Capsid Proteins
Hand
Foot and Mouth Disease
Foot (unit)
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 13, Iss 11, Pp 1733-1741 (2007)
ISSN: 1080-6059
1080-6040
Popis: Human enterovirus 71, but not coxsackievirus A16, is strongly associated with acute neurologic disease.
During 2005, 764 children were brought to a large children’s hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October–November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.
Databáze: OpenAIRE
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