Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005
Autor: | Nguyen Thi Thanh Thao, Peter C. McMinn, Tang Chi Thuong, Mary Jane Cardosa, Nguyen Thi Kim Tien, David Perera, Phan Van Tu, Ooi Mong How, Khanh Huu Truong |
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Rok vydání: | 2007 |
Předmět: |
Microbiology (medical)
Adolescent Epidemiology viruses viral encephalitis lcsh:Medicine medicine.disease_cause Coxsackievirus a16 Hand-foot-and-mouth disease lcsh:Infectious and parasitic diseases 03 medical and health sciences Cell Line Tumor Chlorocebus aethiops medicine Enterovirus 71 Animals Humans lcsh:RC109-216 Child Vero Cells enterovirus 71 Phylogeny 030304 developmental biology 0303 health sciences biology Reverse Transcriptase Polymerase Chain Reaction 030306 microbiology Research Viral encephalitis lcsh:R virus diseases biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification viral skin diseases Throat swab Virology Ho chi minh Enterovirus A Human 3. Good health Infectious Diseases Vietnam Enterovirus Capsid Proteins Hand Foot and Mouth Disease Foot (unit) |
Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 13, Iss 11, Pp 1733-1741 (2007) |
ISSN: | 1080-6059 1080-6040 |
Popis: | Human enterovirus 71, but not coxsackievirus A16, is strongly associated with acute neurologic disease. During 2005, 764 children were brought to a large children’s hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October–November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity. |
Databáze: | OpenAIRE |
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