Haematological Effects of Intermittent Pneumatic Compression for Deep Vein Thrombosis Prophylaxis
| Autor: | Rhys Morris, C. Heledd Roberts |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Risk
0301 basic medicine medicine.medical_specialty Deep vein Intermittent pneumatic compression Hemodynamics 030204 cardiovascular system & hematology Hemorrhagic Disorders Tissue plasminogen activator Fibrin Fibrinogen Degradation Products 03 medical and health sciences 0302 clinical medicine Tissue factor pathway inhibitor Internal medicine Plasminogen Activator Inhibitor 1 medicine Humans Platelet activation skin and connective tissue diseases Intermittent Pneumatic Compression Devices Venous Thrombosis business.industry Fibrinolysis Thrombin Thrombosis Hematology Platelet Activation medicine.disease Thrombelastography 030104 developmental biology medicine.anatomical_structure Cardiology sense organs Carrier Proteins business Plasminogen activator Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 120:912-923 |
| ISSN: | 2567-689X 0340-6245 |
| Popis: | Intermittent pneumatic compression (IPC) is a widely used and recommended method to prevent deep vein thrombosis. While the haemodynamic effects of IPC are well understood, the objective of this systematic review was to analyse the evidence for additional haematological changes. Forty-eight studies were identified where the haematological effects of IPC were measured. The many differences between the studies prevented meta-analysis, but there was a significant amount of evidence that global fibrinolytic activity was increased by IPC, and that levels of D-dimer and tissue factor pathway inhibitor in the blood also increased. There was less consistent evidence for changes in tissue plasminogen activator, plasminogen activator inhibitor and other fibrinolytic parameters. The evidence for changes in pro-coagulant factors and many measures of platelet activation was weak, but there was evidence for increases in prostacyclin. There is sufficient evidence to conclude that IPC does produce haematological changes, but not enough data to clarify the detail of those changes or to determine if it is mediated more by direct compression of the blood vessels, or by the flow changes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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