TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis
| Autor: | Bourdon Paul R, Yves Chicheportiche, Yen-Ming Hsu, Jeffrey L. Browning, Hamish S. Scott, Catherine Hession, Irène Garcia, Haoda Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Programmed cell death
Chemokine DNA Complementary medicine.medical_treatment Molecular Sequence Data Apoptosis Biology Adenocarcinoma ddc:616.07 Carrier Proteins/genetics/ metabolism/secretion Ligands Tumor Necrosis Factor-alpha/ metabolism Biochemistry Mice Sequence Homology Nucleic Acid medicine Tumor Cells Cultured Animals Humans Amino Acid Sequence Molecular Biology Cytokine TWEAK Base Sequence Sequence Homology Amino Acid Tumor Necrosis Factor-alpha Chromosome Mapping Cell Biology Blotting Northern Chemokines/secretion Cell biology Adenocarcinoma/metabolism/ pathology Cytokine Immunology Tumor Necrosis Factors biology.protein Tumor necrosis factor alpha Signal transduction Chemokines TNFSF12 Carrier Proteins Apoptosis Regulatory Proteins Chromosomes Human Pair 17 Signal Transduction |
| Zdroj: | Journal of Biological Chemistry, Vol. 272, No 51 (1997) pp. 32401-32410 |
| ISSN: | 0021-9258 |
| Popis: | The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. Here we describe a new ligand in this family, designated TWEAK. The mouse and human versions of this protein are unusually conserved with 93% amino acid identity in the receptor binding domain. The protein was efficiently secreted from cells indicating that, like TNF, TWEAK may have the long range effects of a secreted cytokine. TWEAK transcripts were abundant and found in many tissues, suggesting that TWEAK and TRAIL belong to a new group of widely expressed ligands. Like many members of the TNF family, TWEAK was able to induce interleukin-8 synthesis in a number of cell lines. The human adenocarcinoma cell line, HT29, underwent apoptosis in the presence of both TWEAK and interferon-gamma. Thus, TWEAK resembles many other TNF ligands in the capacity to induce cell death; however, the fact that TWEAK-sensitive cells are relatively rare suggests that TWEAK along with lymphotoxins alpha/beta and possibly CD30L trigger death via a weaker, nondeath domain-dependent mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|