High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits

Autor:	Daniel R. Pomaro, Fabiana Ebihara, Ivete Ueda, Leonor do Espírito Santo de Almeida Pinto, Maria Cristina de Oliveira Izar, Dulce Elena Casarini, Andreza O. Santos, Francisco Antonio Helfenstein Fonseca, S.S.M. Ihara
Rok vydání:	2005
Předmět:	Blood Glucose Male medicine.medical_specialty Arteriosclerosis Hypercholesterolemia Angiotensin-Converting Enzyme Inhibitors Diabetes Mellitus Experimental chemistry.chemical_compound medicine.artery Internal medicine Diabetes mellitus Alloxan Tetrahydroisoquinolines medicine Animals Pharmacology Aorta Triglyceride Cholesterol Quinapril medicine.disease Endocrinology chemistry Basal (medicine) ACE inhibitor Rabbits Cardiology and Cardiovascular Medicine medicine.drug
Zdroj:	Journal of cardiovascular pharmacology. 45(4)
ISSN:	0160-2446
Popis:	Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single dose of alloxan (100 mg/kg, IV), and, according to plasma glucose levels obtained after 1 week, the animals were divided into 2 groups (≥250 mg/dL or
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b82076ef5be20ef5ff040e7ec6a2d2 https://pubmed.ncbi.nlm.nih.gov/15772516 Zobrazit plný text záznamu